Associations between Silicone Skin Cast Score, Cumulative Sun Exposure, and Other Factors in the Ausimmune Study: A Multicenter Australian Study
| Autor: | Trevor J. Kilpatrick, Caron Chapman, Terence Dwyer, Ingrid van der Mei, Robyn M. Lucas, David R. Williams, Anne-Louise Ponsonby, Michael P. Pender, Keith Dear, Anthony J. McMichael, Bruce V. Taylor, Patricia C. Valery, Alan Coulthard |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Adult
Male medicine.medical_specialty Adolescent Epidemiology Silicones Sunburn Skin Pigmentation Young Adult Risk Factors medicine Humans Young adult Sunlight integumentary system business.industry Australia Case-control study Environmental Exposure Odds ratio Environmental exposure Middle Aged Prognosis medicine.disease Dermatology Confidence interval Skin Aging Surgery Oncology Case-Control Studies Female Skin cancer business |
| Zdroj: | Cancer Epidemiology, Biomarkers & Prevention. 18:2887-2894 |
| ISSN: | 1538-7755 1055-9965 |
| DOI: | 10.1158/1055-9965.epi-09-0191 |
| Popis: | Past sun exposure is linked to a wide range of disease outcomes but is difficult to measure accurately. Silicone skin casts measure skin damage, but some studies show that age rather than sun exposure is the most important determinant of cast score. We examined skin damage scores from silicone casts of the back of the hand in a large adult sample (n = 534) with a broad range of past cumulative UV radiation (UVR) doses. Participants were ages 18 to 61 years and resided in one of four locations down the eastern Australian seaboard, spanning 27-43°S. Data were collected by questionnaire and during a nurse-led interview and examination. Silicone casts were graded from 1 to 6, where higher score represents greater damage. Higher skin damage score was associated with lighter skin pigmentation [adjusted odds ratio (AOR), 4.51; 95% confidence interval (95% CI), 2.33-8.75], fairer natural hair color, particularly red hair (AOR, 11.31; 95% CI, 4.08-31.36), and blue/gray eyes (AOR, 1.72; 95% CI, 1.14-2.59). Higher cumulative UVR dose, particularly before age 18 years, was associated with higher skin damage score (AOR, 2.06; 95% CI, 1.15-2.67 per 1,000 KJ/m2), as was number of sunburns, even after adjustment for cumulative UVR dose (AOR, 2.86; 95% CI, 1.50-5.43 for >10 sunburns ever compared with no sunburns ever). Silicone casts of the dorsum of the hand provide a measure of cumulative UVR dose and number of sunburns over the lifetime, which persists after adjustment for chronological age. They can be used as an objective measure of cumulative past sun exposure in epidemiologic studies, but other determinants of skin damage, such as skin pigmentation, should be concurrently evaluated. (Cancer Epidemiol Biomarkers Prev 2009;18(11):2887–94) |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|