Miniature stick-packaging--an industrial technology for pre-storage and release of reagents in lab-on-a-chip systems
| Autor: | Jan Smetana, Roland Zengerle, Felix von Stetten, Thomas van Oordt, Yannick Barb |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
Rapid prototyping
Engineering drawing Ultrasonic welding Engineering Miniaturization business.industry Microfluidics Biomedical Engineering Bioengineering General Chemistry Equipment Design Lab-on-a-chip Microfluidic Analytical Techniques Biochemistry Seal (mechanical) law.invention Industrial technology Volume (thermodynamics) law Reagent Pressure Product Packaging Indicators and Reagents Process engineering business |
| Zdroj: | Lab on a chip. 13(15) |
| ISSN: | 1473-0189 |
| Popis: | Stick-packaging of goods in tubular-shaped composite-foil pouches has become a popular technology for food and drug packaging. We miniaturized stick-packaging for use in lab-on-a-chip (LOAC) systems to pre-store and on-demand release the liquid and dry reagents in a volume range of 80–500 μl. An integrated frangible seal enables the pressure-controlled release of reagents and simplifies the layout of LOAC systems, thereby making the package a functional microfluidic release unit. The frangible seal is adjusted to defined burst pressures ranging from 20 to 140 kPa. The applied ultrasonic welding process allows the packaging of temperature sensitive reagents. Stick-packs have been successfully tested applying recovery tests (where 99% (STDV = 1%) of 250 μl pre-stored liquid is released), long-term storage tests (where there is loss of only |
| Databáze: | OpenAIRE |
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