Histopathological Changes of Organs (Lungs, Liver, Kidney, and Brain) After Using Two Types of AgiCoat and Acticoat Nanosilver Dressings on Deep Second-Degree Burn in Rat
| Autor: | Babak Jafarnejad, Ali-Mohammad Karimi, Noor-Ahmad Latifi, Hamid Karimi, Ali Zare Mehrjerdi |
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| Rok vydání: | 2019 |
| Předmět: |
Male
medicine.medical_specialty Pathology Polyesters Metal Nanoparticles Spleen Absorption (skin) Kidney Rats Sprague-Dawley 03 medical and health sciences 0302 clinical medicine medicine Animals Second-Degree Burn Lung Wound Healing 0303 health sciences business.industry Rehabilitation Brain Silver Compounds 030311 toxicology 030208 emergency & critical care medicine Bandages Rats Disease Models Animal medicine.anatomical_structure Liver Toxicity Anti-Infective Agents Local Emergency Medicine Surgery Histopathology Polyethylenes Burns Wound healing business |
| Zdroj: | Journal of Burn Care & Research. 41:141-150 |
| ISSN: | 1559-0488 1559-047X |
| DOI: | 10.1093/jbcr/irz137 |
| Popis: | Prevention of infections is a very important issue in treating the burn wounds. The nanosilver dressings have many promising advantages, but absorption of silver ions and its adverse effects to the body were always a question. The aim of this study was to compare Silver serum levels and acute toxic effects of nanosilver on histopathology of organs (lungs, liver, kidney, spleen, and brain) in two types of AgiCoat and Acticoat (nanosilver) dressings on second-degree deep burn in rat. This is an experimental study conducted in our animal laboratory. We divided 24 Sprague–Dawley male rats weighing 300 to 350 randomly into two groups. After anesthesia, a second deep-degree burn was made over dorsal skins of rats by standard method. For group A, Agicoat and, for group B, Acticoat dressings were used. The dressings were changed every 3 days with AgiCoat and Acticoat, respectively. After 14 days, we got blood samples and tissue samples taken from heart, liver, kidneys, spleen, lungs, and brain and a sample from dorsal skin of the rat for histopathological examinations. The results showed that the levels of serum silver in both groups were significantly higher than the standard level (1.22 part per million (PM); AgiCoat, P = .017; Acticoat, P = .000), but there was no significant difference between the groups (P = .551). Examination of the relationship between the level of serum silver and histopathological changes in liver showed that hepatotoxicity of AgiCoat was higher compared with Acticoat and the difference was significant (P = .002). There were no pathological changes in brain, kidneys, spleen, heart, and lungs. Wound healing was faster in Acticoat group. The nanosilver dressings can cause toxicity in liver but not in kidney, brain, spleen, heart, and lungs. Liver pathology and hepatotoxicity were more prominent in AgiCoat group. Wound healing was faster in Acticoat group. |
| Databáze: | OpenAIRE |
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