Mitochondria as a possible target for nicotine action
| Autor: | Mariusz R. Wieckowski, Carole Mathis, Monika Prill, Jarosław Walczak, Karsta Luettich, Joanna Szczepanowska, Marco van der Toorn, Karolina Drabik, Jędrzej Szymański, Dominika Malinska, Paulina Patalas-Krawczyk, Manuel C. Peitsch, Jerzy Duszyński, Julia Hoeng, Bernadeta Michalska |
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| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Nicotine Cellular adaptation Physiology Context (language use) adaptation Mitochondrion Biology Cigarette Smoking 03 medical and health sciences 0302 clinical medicine Mitophagy medicine Animals Humans Neurodegeneration Cell Biology Mini-Review medicine.disease Mitochondria Cell biology Oxidative Stress 030104 developmental biology Mitochondrial respiratory chain Electron Transport Chain Complex Proteins Mechanism of action 030220 oncology & carcinogenesis Calcium medicine.symptom medicine.drug |
| Zdroj: | Journal of Bioenergetics and Biomembranes |
| ISSN: | 1573-6881 0145-479X |
| Popis: | Mitochondria are multifunctional and dynamic organelles deeply integrated into cellular physiology and metabolism. Disturbances in mitochondrial function are involved in several disorders such as neurodegeneration, cardiovascular diseases, metabolic diseases, and also in the aging process. Nicotine is a natural alkaloid present in the tobacco plant which has been well studied as a constituent of cigarette smoke. It has also been reported to influence mitochondrial function both in vitro and in vivo. This review presents a comprehensive overview of the present knowledge of nicotine action on mitochondrial function. Observed effects of nicotine exposure on the mitochondrial respiratory chain, oxidative stress, calcium homeostasis, mitochondrial dynamics, biogenesis, and mitophagy are discussed, considering the context of the experimental design. The potential action of nicotine on cellular adaptation and cell survival is also examined through its interaction with mitochondria. Although a large number of studies have demonstrated the impact of nicotine on various mitochondrial activities, elucidating its mechanism of action requires further investigation. |
| Databáze: | OpenAIRE |
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