Stromal cell regulation of homeostatic and inflammatory lymphoid organogenesis

Autor:	Matthew J. W. Kain, Benjamin M. J. Owens
Rok vydání:	2013
Předmět:	Stromal cell Lymphoid Tissue Organogenesis Immunology Antigen-Presenting Cells Inflammation Biology Adaptive Immunity Antigen medicine Immunology and Allergy Animals Homeostasis Humans Lymphopoiesis Antigen-presenting cell Review Articles Innate lymphoid cell Models Immunological Acquired immune system Lymphatic system Cancer research medicine.symptom Stromal Cells
Zdroj:	Immunology. 140(1)
ISSN:	1365-2567
Popis:	Secondary lymphoid organs function to increase the efficiency of interactions between rare, antigen-specific lymphocytes and antigen presenting cells, concentrating antigen and lymphocytes in a supportive environment that facilitates the initiation of an adaptive immune response. Homeostatic lymphoid tissue organogenesis proceeds via exquisitely controlled spatiotemporal interactions between haematopoietic lymphoid tissue inducer populations and multiple subsets of non-haematopoietic stromal cells. However, it is becoming clear that in a range of inflammatory contexts, ectopic or tertiary lymphoid tissues can develop inappropriately under pathological stress. Here we summarize the role of stromal cells in the development of homeostatic lymphoid tissue, and assess emerging evidence that suggests a critical role for stromal involvement in the tertiary lymphoid tissue development associated with chronic infections and inflammation.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43b1a4149e81623e3d8af53a2a6e3cac https://pubmed.ncbi.nlm.nih.gov/23621403 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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