Dextrose solution for priming and rinsing the extracorporeal circuit in hemodialysis patients: A prospective pilot study
| Autor: | Yanna Dou, Paul A. Rootjes, Jochen G. Raimann, Peter Kotanko, Erik L. Penne, Georges Ouellet, Stephan Thijssen |
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| Přispěvatelé: | Nephrology, ACS - Atherosclerosis & ischemic syndromes |
| Rok vydání: | 2021 |
| Předmět: |
Adult
Male sodium loading Short Communication medicine.medical_treatment 030232 urology & nephrology Biomedical Engineering Volume overload Medicine (miscellaneous) Blood Pressure Pilot Projects Bioengineering Priming (agriculture) 030204 cardiovascular system & hematology Artificial kidney Extracorporeal Biomaterials artificial kidney 03 medical and health sciences 0302 clinical medicine Renal Dialysis medicine Humans Prospective Studies Saline apheresis and detoxification techniques Aged Excess sodium Dextrose solution business.industry Sodium interdialytic weight gain General Medicine Middle Aged dialysis fluids dextrose 5% Glucose thirst Hemodialysis Anesthesia Apheresis Dialysis and Liver Support extracorporeal circuit Kidney Failure Chronic isotonic saline business priming and rinsing |
| Zdroj: | The International Journal of Artificial Organs Rootjes, P A, Penne, E L, Ouellet, G, Dou, Y, Thijssen, S, Kotanko, P & Raimann, J G 2021, ' Dextrose solution for priming and rinsing the extracorporeal circuit in hemodialysis patients: A prospective pilot study ', International Journal of Artificial Organs, vol. 44, no. 11, pp. 906-911 . https://doi.org/10.1177/03913988211020023 International Journal of Artificial Organs, 44(11), 906-911. Wichtig Publishing |
| ISSN: | 1724-6040 0391-3988 |
| Popis: | Introduction: Excess sodium intake and consequent volume overload are major clinical problems in hemodialysis (HD) contributing to adverse outcomes. Saline used for priming and rinsing of the extracorporeal circuit is a potentially underappreciated source of intradialytic sodium gain. We aimed to examine the feasibility and clinical effects of replacing saline as the priming and rinsing fluid by a 5% dextrose solution. Materials and methods: We enrolled non-diabetic and anuric stable HD patients. First, the extracorporeal circuit was primed and rinsed with approximately 200–250 mL of isotonic saline during 4 weeks (Phase 1), subsequently a similar volume of a 5% dextrose solution replaced the saline for another 4 weeks (Phase 2), followed by another 4 weeks of saline (Phase 3). We collected data on interdialytic weight gain (IDWG), pre- and post-dialysis blood pressure, intradialytic symptoms, and thirst. Results: Seventeen chronic HD patients (11 males, age 54.1 ± 18.7 years) completed the study. The average priming and rinsing volumes were 236.7 ± 77.5 and 245.0 ± 91.8 mL respectively. The mean IDWG did not significantly change (2.52 ± 0.88 kg in Phase 1; 2.28 ± 0.70 kg in Phase 2; and 2.51 ± 1.2 kg in Phase 3). No differences in blood pressures, intradialytic symptoms or thirst were observed. Conclusions: Replacing saline by 5% dextrose for priming and rinsing is feasible in stable HD patients and may reduce intradialytic sodium loading. A non-significant trend toward a lower IDWG was observed when 5% dextrose was used. Prospective studies with a larger sample size and longer follow-up are needed to gain further insight into the possible effects of using alternate priming and rinsing solutions lowering intradialytic sodium loading. Trial registration: Identifier NCT01168947 (ClinicalTrials.gov). |
| Databáze: | OpenAIRE |
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