The role of circulating tumor cells and K-ras mutations in patients with locally advanced rectal cancer: a prospective study

Autor:	Somaya Ezzat, Hussein M. Khaled, Yasser Abdelazim, Abdel-Rahman N. Zekri, Mona S Abdellateif, Abeer A. Bahnassy, Asmaa Salama, Marwa Mohanad
Rok vydání:	2020
Předmět:	0301 basic medicine Adult Male medicine.medical_specialty Colorectal cancer Locally advanced Gene Expression Antineoplastic Agents Malignancy medicine.disease_cause Gastroenterology Proto-Oncogene Proteins p21(ras) 03 medical and health sciences 0302 clinical medicine Circulating tumor cell Internal medicine Genetics Medicine Humans In patient Prospective Studies Intestinal Mucosa Prospective cohort study Molecular Biology Pathological Aged Neoplasm Staging Mutation business.industry Rectal Neoplasms Carcinoma General Medicine Middle Aged medicine.disease Neoplastic Cells Circulating Prognosis Survival Analysis Neoadjuvant Therapy 030104 developmental biology Treatment Outcome 030220 oncology & carcinogenesis Female Neoplasm Grading business
Zdroj:	Molecular biology reports. 47(12)
ISSN:	1573-4978
Popis:	Rectal cancer is a common malignancy with a relatively poor prognosis. We assessed the possible prognostic and predictive role(s) of circulating tumor cells (CTCs) and K-ras mutations in locally advanced rectal carcinoma (LARC) patients. CTCs number and K-ras mutation status were assessed in the Peripheral blood and tumor tissue samples of 60 patients with LARC compared to control group (normal rectal mucosa). Data were correlated to relevant clinico-pathological features, response to treatment, disease free (DFS) and overall survival (OS) rates. K-ras mutations were present in 24/60 (40%) patients. Baseline CTCs (
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43acd3d84423764a8de797fe5e387a03 https://pubmed.ncbi.nlm.nih.gov/33174084 Zobrazit plný text záznamu Full text from SpringerLink