Failure of carnitine in improving hepatic nitrogen content in alcoholic and non-alcoholic malnourished rats
| Autor: | Alceu Afonso Jordão, Gilberto João Padovan, Vivian Marques Miguel Suen, Julio Sérgio Marchini, Luciana P. Rodrigues, Guilherme Vannucchi Portari |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2010 |
| Předmět: |
Male
medicine.medical_specialty Normal diet Nitrogen chemistry.chemical_element Alcohol Fatty Acids Nonesterified Weight Gain Protein-Energy Malnutrition Excretion Random Allocation chemistry.chemical_compound Carnitine Internal medicine L‐carnitine medicine L-carnitine Animals Liver fat Rats Wistar Liver nitrogen lcsh:R5-920 Methionine Ethanol business.industry General Medicine medicine.disease Rats Fatty Liver Malnutrition Undernourishment Alcoholism Basic Research Endocrinology Liver chemistry Dietary Supplements Vitamin B Complex Glycine business lcsh:Medicine (General) medicine.drug |
| Zdroj: | Clinics, Vol 65, Iss 9, Pp 877-883 (2010) Clinics; v. 65 n. 9 (2010); 877-883 Clinics; Vol. 65 Núm. 9 (2010); 877-883 Clinics; Vol. 65 No. 9 (2010); 877-883 Clinics Universidade de São Paulo (USP) instacron:USP Clinics, Volume: 65, Issue: 9, Pages: 877-883, Published: 2010 |
| ISSN: | 1980-5322 1807-5932 |
| Popis: | AIMS: To investigate the effect of carnitine supplementation on alcoholic malnourished rats' hepatic nitrogen content. METHODS: Malnourished rats, on 50% protein‐calorie restriction with free access to water (malnutrition group) and malnourished rats under the same conditions with free access to a 20% alcohol/water solution (alcohol group) were studied. After the undernourishment period (4 weeks with or without alcohol), both groups were randomly divided into two subgroups, one of them nutritionally recovered for 28 days with free access to a normal diet and water (recovery groups) and the other re‐fed with free access to diet and water plus carnitine (0.1 g/g body weight/day by gavage) (carnitine groups). No alcohol intake was allowed during the recovery period. RESULTS: The results showed: i) no difference between the alcohol/no alcohol groups, with or without carnitine, regarding body weight gain, diet consumption, urinary nitrogen excretion, plasma free fatty acids, lysine, methionine, and glycine. ii) Liver nitrogen content was highest in the carnitine recovery non‐alcoholic group (from 1.7 to 3.3 g/100 g, P.05) was highest in the alcoholic animals. CONCLUSION: Carnitine supplementation did not induce better nutritional recovery. |
| Databáze: | OpenAIRE |
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