Plasma diazepam levels after single dose oral and intramuscular administration
| Autor: | R. A. E. Assaf, John W. Dundee, J. A. S. Gamble |
|---|---|
| Rok vydání: | 1975 |
| Předmět: |
Adult
Male Chromatography Gas Time Factors Population Administration Oral Body weight Injections Intramuscular Oral administration medicine Humans education education.field_of_study Clinical Trials as Topic Physician-Patient Relations Diazepam Adult female business.industry Body Weight Plasma levels Anesthesiology and Pain Medicine Rapid rise Anesthesia business Nurse-Patient Relations Preanesthetic Medication medicine.drug |
| Zdroj: | Anaesthesia. 30(2) |
| ISSN: | 0003-2409 |
| Popis: | Plasma diazepam levels were estimated by gas-liquid chromatography following a single 10 mg dose administered to a health adult female population by the oral and intramuscular routes. The highest levels were achieved following oral administration, reaching a peak at 60 minutes, although injection into the thigh resulted in a more rapid rise initially. Injection into this site produced higher levels than when the buttock was used. Injection by nurses into the latter site produced particularly low plasma levels over the 90-minute period of study. The plasma levels found at 90 minutes following the oral and thigh routes were found to be closely correlated with the weight of the patient. |
| Databáze: | OpenAIRE |
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