| Autor: |
Oksana Raskosha, Lyudmila Bashlykova, Natalia Starobor |
| Rok vydání: |
2022 |
| Předmět: |
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| Zdroj: |
International journal of radiation biology. |
| ISSN: |
1362-3095 |
| Popis: |
The aim of this work is to assess DNA damage in the somatic and germ cells in root voles living for a long time under conditions of an increased radiation background and to examine the of manifestation of long-term consequences in their offspring.Using the DNA comet assay (neutral version), we assessed the proportion of cells with DNA damage in the cells of the thyroid, bone marrow and testicular in root voles (In animals caught in a radioactively contaminated area, the level of DNA fragmentation in the thyroid gland, bone marrow and testicular remained within the range of values of control animals. The studies that we continued on the offspring of irradiated root voles that were developing in the vivarium under normal radiation background allowed us to identify an increase in the level of DNA DSBs in the thyroid gland in the FThe data obtained on voles from the experimental site indicate adaptation to habitat conditions in a radioactively polluted environment. The provocative effect of urethane made it possible to reveal different response of organs with different proliferative activity. Long-term habitation of voles under conditions of an increased radiation background led to genome instability in their offspring. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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