Effects of different intraabdominal pressure levels on oxidative stress markers in laparoscopic cholecystectomy
| Autor: | Tuğrul Çakır, Uğur Doğan, Burhan Mayir, Mehmet Tahir Oruç, Mani Habibi, Umit Koc, Hamit Yasar Ellidag, Arif Aslaner, Nurullah Bülbüller, Ismail Gomceli |
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| Rok vydání: | 2018 |
| Předmět: |
medicine.medical_specialty
business.industry General surgery Ischemia-modified albumin Perioperative medicine.disease medicine.disease_cause 03 medical and health sciences Antioxidant capacity 0302 clinical medicine Pneumoperitoneum 030220 oncology & carcinogenesis Anesthesia medicine Intraabdominal pressure Original Article 030211 gastroenterology & hepatology In patient business Laparoscopic cholecystectomy Oxidative stress |
| Zdroj: | Turkish Journal of Surgery. 34:212-216 |
| ISSN: | 2564-7032 2564-6850 |
| DOI: | 10.5152/turkjsurg.2017.3906 |
| Popis: | OBJECTIVE To evaluate the effect of laparoscopic cholecystectomy performed under different intraabdominal pressure on oxidative stress markers. MATERIAL AND METHODS This prospective, randomized, controlled study examined 90 consecutive healthy patients who underwent elective laparoscopic cholecystectomy with the diagnosis of symptomatic cholelithiasis. The patients were divided into three groups, 30 patients in each. Group 1 included patients who underwent laparoscopic cholecystectomy at a CO2 pneumoperitoneum pressure of 7 mmHg, Group 2 patients who underwent laparoscopic cholecystectomy at a CO2 pneumoperitoneum pressure of 10 mmHg, and Group 3 patients who underwent laparoscopic cholecystectomy at a CO2 pneumoperitoneum pressure of 13 mmHg. Blood samples were collected preoperatively, perioperatively, and postoperatively for measurement of the serum levels of ischemia modified albumin and an analysis of total antioxidant status and total oxidant status. Intra-group comparisons were made. RESULTS Group 1 experienced a significant increase in the postoperative ischemia modified albumin values compared to preoperative ischemia modified albumin values (p=0.013). Group 2 experienced a significant decrease in the perioperative total antioxidant status values compared to preoperative and postoperative total antioxidant status values (p=0.009). Group 3 experienced a significant increase in the perioperative total oxidant status and oxidative stress index values compared to preoperative values (p |
| Databáze: | OpenAIRE |
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