Macular vessel density and foveal avascular zone parameters in patients after acute primary angle closure determined by OCT angiography

Autor: Yi Xu, Haibo Jiang, Ping-Bao Wang, Jing Zou, Hui-Zhuo Xu, Fangling Li, Xueyan Yao, Bei Xu, Hua Wang, Kangcheng Liu
Rok vydání: 2020
Předmět:
Male
0301 basic medicine
Fovea Centralis
genetic structures
lcsh:Medicine
Glaucoma
Diseases
Corneal Diseases
Prognostic markers
0302 clinical medicine
Oct angiography
Macula Lutea
Fluorescein Angiography
lcsh:Science
Signs and symptoms
Multidisciplinary
Middle Aged
Prognosis
Area Under Curve
Female
Glaucoma
Angle-Closure
Tomography
Optical Coherence
medicine.medical_specialty
Predictive markers
Article
Perimeter
03 medical and health sciences
Medical research
Vessel density
Ophthalmology
medicine
Humans
In patient
Eye manifestations
Eye diseases
Aged
business.industry
lcsh:R
Retinal Vessels
Diagnostic markers
Optical coherence tomography angiography
Foveal avascular zone
medicine.disease
eye diseases
Primary angle closure suspect
030104 developmental biology
Preclinical research
Case-Control Studies
030221 ophthalmology & optometry
lcsh:Q
sense organs
business
Biomarkers
Zdroj: Scientific Reports
Scientific Reports, Vol 10, Iss 1, Pp 1-11 (2020)
ISSN: 2045-2322
DOI: 10.1038/s41598-020-73223-9
Popis: This study analyzed the optical coherence tomography angiography (OCTA) macular parameters in primary angle-closure glaucoma (PACG) patients after acute primary angle closure (APAC) episodes. Thirty-three patients with 33 APAC eyes and 33 primary angle closure suspect (PACS) eyes and 33 age-matched normal subjects (controls) were enrolled. Macular vessel density (VD) in central, inner, outer and full regions and foveal avascular zone (FAZ) parameters (area, perimeter and circularity index) were compared between APAC, PACS, and control eyes. For resolved APAC eyes, the VD in each macular region was significantly lower than that in control eyes, with less central and inner macular VD than PACS eyes. The central macular VD was significantly lower in PACS eyes than in controls. There was no difference in FAZ area and perimeter between APAC, PACS, and control eyes. FAZ circularity was highest in control eyes, followed by PACS eyes, and lowest in APAC eyes. The AUC, sensitivity and specificity of FAZ circularity were 0.944, 93.9% and 84.8%, respectively, in APAC eyes and 0.881, 84.8% and 81.8%, respectively, in PACS eyes. Therefore, FAZ circularity had the best discrimination capability for detecting both APAC and PACS eyes. Macular assessment with OCTA could provide an accurate early-stage diagnostic tool for PACG.
Databáze: OpenAIRE
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