A combination of scGOS/lcFOS with Bifidobacterium breve M-16V protects suckling rats from rotavirus gastroenteritis

Autor: Jan Knol, Karen Knipping, Àngels Franch, Sandra Saldaña-Ruíz, K. van Limpt, Johan Garssen, Francisco J. Pérez-Cano, Margarida Castell, Maria del Mar Rigo-Adrover
Rok vydání: 2016
Předmět:
Rotavirus
0301 basic medicine
suckling animal
medicine.medical_treatment
ved/biology.organism_classification_rank.species
Prebiotic
Medicine (miscellaneous)
Synbiotics
Bifidobacterium breve
Probiotic
Antibodies
Viral
medicine.disease_cause
immune response
law.invention
Feces
0302 clinical medicine
law
antibody
Taverne
synbiotic agent
probiotic agent
Nutrition and Dietetics
FOS
Rotavirus infection
Gastroenteritis
Diarrhea
030211 gastroenterology & hepatology
medicine.symptom
enteric feeding
animal experiment
Context (language use)
Biology
virus shedding
Rotavirus Infections
animal tissue
Specimen Handling
03 medical and health sciences
Immune system
medicine
Animals
Viral shedding
model
nonhuman
ved/biology
animal model
disease model
Probiotics
GOS
Body Weight
antibody response
Fatty Acids
Volatile
infant
Immunoglobulin A
Rats
Synbiotic
Disease Models
Animal
Prebiotics
030104 developmental biology
Animals
Newborn
Immunoglobulin M
Rats
Inbred Lew
prebiotic agent
Immunology
Zdroj: European Journal of Nutrition, 1. Dr. Dietrich Steinkopff Verlag GmbH and Co. KG
STARTPAGE=1;ISSN=1436-6207;TITLE=European Journal of Nutrition
ISSN: 1436-6215
1436-6207
DOI: 10.1007/s00394-016-1213-1
Popis: Purpose: Rotavirus (RV) is the leading cause of severe diarrhoea among infants and young children, and although more standardized studies are needed, there is evidence that probiotics can help to fight against RV and other infectious and intestinal pathologies. On the other hand, the effects of prebiotics have not been properly addressed in the context of an RV infection. The aim of this study was to demonstrate a protective role for a specific scGOS/lcFOS 9:1 prebiotic mixture (PRE) separately, the probiotic Bifidobacterium breve M-16V (PRO) separately and the combination of the prebiotic mixture and the probiotic (synbiotic, SYN) in a suckling rat RV infection model. Methods: The animals received the intervention from the 3rd to the 21st day of life by oral gavage. On day 7, RV was orally administered. Clinical parameters and immune response were evaluated. Results: The intervention with the PRO reduced the incidence, severity and duration of the diarrhoea (p
Databáze: OpenAIRE
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