The amnesic shellfish poison domoic acid enhances neurotoxicity by excitatory amino acids in cultured neurons
| Autor: | J Kispert, Angeles Torreblanca, V. Zitko, Santiago Gascón, M. T. Fernández-Sánchez, Antonello Novelli |
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| Rok vydání: | 1992 |
| Předmět: |
chemistry.chemical_classification
Organic Chemistry Clinical Biochemistry Neurotoxicity Domoic acid Long-term potentiation Glutamic acid Pharmacology Biology medicine.disease Biochemistry Amino acid chemistry.chemical_compound chemistry Amnesic shellfish poisoning Aspartic acid medicine NMDA receptor |
| Zdroj: | Amino Acids. 2:233-244 |
| ISSN: | 1438-2199 0939-4451 |
| DOI: | 10.1007/bf00805945 |
| Popis: | A recent episode of human intoxication by cultured mussels containing a rare excitatory amino acid named domoic acid, received particular attention for its neurological implications. The intoxication produced neurological problems, such as headache, confusion, and loss of memory, particularly severe at times. Neuronal damage was found in the hippocampus and amygdala of four patients. We now report that in neuronal cultures the neurotoxicity of a domoic acid-containing mussel extract is the result of domoic acid potentiation of the excitotoxic effect of glutamic acid and aspartic acid present in high amounts in mussel tissue. Moreover, we show that subtoxic concentrations of domoic acid are sufficient to potentiate glutamic acid and aspartic acid neurotoxicity. We present evidence suggesting that the neurotoxic synergism may be due to a reduction of Mg(+ +) block at the NMDA receptor-associated channel, following activation of NON-NMDA receptors by domoic acid. |
| Databáze: | OpenAIRE |
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