Decreased cerebral blood flow of the right anterior cingulate cortex in long-term and short-term abstinent methamphetamine users
| Autor: | Soojeong C. Bae, Young Hoon Sung, Jaeuk Hwang, Sung Nam Cho, Seog Ju Kim, Perry F. Renshaw, Dong Soo Lee, Ho Young Lee, In Kyoon Lyoo |
|---|---|
| Rok vydání: | 2005 |
| Předmět: |
Cingulate cortex
Adult Male Alcohol Drinking Substance-Related Disorders media_common.quotation_subject Hemodynamics Brodmann area 32 Single-photon emission computed tomography Toxicology Gyrus Cinguli Functional Laterality Methamphetamine Reference Values mental disorders medicine Humans Pharmacology (medical) Anterior cingulate cortex media_common Pharmacology Tomography Emission-Computed Single-Photon medicine.diagnostic_test Abstinence Psychiatry and Mental health medicine.anatomical_structure nervous system Cerebral blood flow Anesthesia Cerebrovascular Circulation Female Psychology circulatory and respiratory physiology medicine.drug |
| Zdroj: | Drug and alcohol dependence. 82(2) |
| ISSN: | 0376-8716 |
| Popis: | Background The aim of the current study was to explore changes of relative regional cerebral blood flow (rCBF) in short-term and long-term abstinent methamphetamine (MA) users. Methods Relative rCBF in 40 abstinent MA users and 23 healthy comparison subjects was compared by the technetium-99m-hexamethyl-propylene amine oxime ( 99m Tc-HMPAO) single photon emission computed tomography (SPECT). Relative rCBF in areas that were found to differ significantly was also compared in groups of MA users with short-term ( Results MA users showed decreased relative rCBF in the right anterior cingulate cortex (Brodmann area 32) relative to healthy comparison subjects. Long-term abstinent MA users had significantly greater rCBF than short-term abstinent MA users. Conclusions We report that abstinent MA users have decreased rCBF in the anterior cingulate cortex with smaller relative decreases in subjects with prolonged abstinence. |
| Databáze: | OpenAIRE |
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