Platelet activation status in the diagnosis and postoperative prognosis of hepatocellular carcinoma
| Autor: | Baishen Pan, Xiao-Lu Ma, Shuang-Jian Qiu, Xin-Rong Yang, Wei Guo, Jie Zhu, Yun-Feng Cheng, Jian Zhou, Hao Wang, Jia Fan, Beili Wang |
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| Rok vydání: | 2019 |
| Předmět: |
Male
0301 basic medicine medicine.medical_specialty Carcinoma Hepatocellular Clinical Biochemistry Biochemistry Gastroenterology 03 medical and health sciences 0302 clinical medicine Recurrence Internal medicine medicine Humans Platelet Postoperative Period Platelet activation Neoplasm Metastasis Risk factor Prospective cohort study Univariate analysis Receiver operating characteristic Proportional hazards model business.industry Liver Neoplasms Biochemistry (medical) General Medicine Middle Aged Platelet Activation Prognosis medicine.disease 030104 developmental biology 030220 oncology & carcinogenesis Hepatocellular carcinoma Female business Biomarkers |
| Zdroj: | Clinica Chimica Acta. 495:191-197 |
| ISSN: | 0009-8981 |
| DOI: | 10.1016/j.cca.2019.03.1634 |
| Popis: | Background The venous thromboembolism, which may be caused by increased platelet activation, is a risk factor for tumor prognosis. We determined the platelet activation status for diagnosis and predicting postoperative prognosis of hepatocellular carcinoma. Methods We conducted a prospective study of 191 patients diagnosed with HCC at Zhongshan Hospital from April 2016 to July 2016 as well as 99 healthy people. The platelet activation status was assessed by 2 platelet markers, PAC-1 and CD62p, using flow cytometry. The patients were treated with TACE or resection and monitored for ≥6 months. The diagnostic value of marker-positive platelets was determined by the receiver operating characteristic curve and the postoperative value were analyzed using the Kaplan-Meier method and COX regression model. Results All the 3 groups with high levels of marker-positive platelets were likely to be diagnosed with HCC and the PAC-1+ percentage had the best efficacy. The univariate analysis showed that the levels of PAC-1+ and CD62p+ platelets was risker factors for poor postoperative prognosis after both TACE and resection. Moreover, the multivariate analysis revealed that the level of PAC-1+ platelets was an independent risk factor for poor prognosis. Conclusions The PAC-1+ percentage of platelets is a new indicator for diagnosis and predicting postoperative prognosis. |
| Databáze: | OpenAIRE |
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