The First Non-LRV RNA Virus in Leishmania
| Autor: | Tereza Lestinova, Yulia Kleschenko, Petr Volf, Alexander N. Lukashev, Alexei Y. Kostygov, Diego H. Macedo, Natalya Kraeva, Paul A. Bates, Danyil Grybchuk, Pavel Kulich, Vyacheslav Yurchenko |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
030231 tropical medicine lcsh:QR1-502 Genome Viral bunyavirales Virus Article lcsh:Microbiology 03 medical and health sciences chemistry.chemical_compound Mice Open Reading Frames 0302 clinical medicine Virology RNA polymerase parasitic diseases Animals RNA Viruses ORFS leishmania martiniquensis Phylogeny Infectivity Leishmania biology Macrophages RNA High-Throughput Nucleotide Sequencing RNA virus biology.organism_classification RNA-Dependent RNA Polymerase 3. Good health Nucleoprotein 030104 developmental biology Infectious Diseases chemistry leishbunyavirus Reassortant Viruses |
| Zdroj: | Viruses, Vol 12, Iss 2, p 168 (2020) Viruses Volume 12 Issue 2 |
| ISSN: | 1999-4915 |
| Popis: | In this work, we describe the first Leishmania-infecting leishbunyavirus&mdash the first virus other than Leishmania RNA virus (LRV) found in trypanosomatid parasites. Its host is Leishmania martiniquensis, a human pathogen causing infections with a wide range of manifestations from asymptomatic to severe visceral disease. This virus (LmarLBV1) possesses many characteristic features of leishbunyaviruses, such as tripartite organization of its RNA genome, with ORFs encoding RNA-dependent RNA polymerase, surface glycoprotein, and nucleoprotein on L, M, and S segments, respectively. Our phylogenetic analyses suggest that LmarLBV1 originated from leishbunyaviruses of monoxenous trypanosomatids and, probably, is a result of genomic re-assortment. The LmarLBV1 facilitates parasites&rsquo infectivity in vitro in primary murine macrophages model. The discovery of a virus in L. martiniquensis poses the question of whether it influences pathogenicity of this parasite in vivo, similarly to the LRV in other Leishmania species. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
| Nepřihlášeným uživatelům se plný text nezobrazuje | K zobrazení výsledku je třeba se přihlásit. |