Next generation strategy for tuning the thermoresponsive properties of micellar and hydrogel drug delivery vehicles using ionic liquids
| Autor: | Talia A. Shmool, Anna P. Constantinou, Andreas Jirkas, Chen Zhao, Theoni K. Georgiou, Jason P. Hallett |
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| Přispěvatelé: | Engineering & Physical Science Research Council (E, Engineering & Physical Science Research Council (EPSRC) |
| Jazyk: | angličtina |
| Rok vydání: | 2022 |
| Předmět: |
RELEASE
Science & Technology Polymers and Plastics STABILITY Organic Chemistry Polymer Science PROTEIN Bioengineering ENHANCE 0303 Macromolecular and Materials Chemistry Biochemistry POLYOLS GELATION SYNERESIS Physical Sciences BLOCK-COPOLYMER MICELLES 0307 Theoretical and Computational Chemistry TEMPERATURE TRANSITION |
| Popis: | Amongst the greatest challenges in developing injectable controlled thermoresponsive micellar and hydrogel drug delivery vehicles include tuning the cloud point (CP) and reducing the gelation temperature (Tgel), below 37 °C, without compromising stability and solubility. Here, a unique strategy is employed using ionic liquid (IL) matrices to produce stable micellar and hydrogel delivery vehicles of distinct thermoresponsive properties. Each formulation includes the in-house synthesised polymer OEGMA30020-b-BuMA22-b-DEGMA11 with FITC-IgG. Both micellar-IL and hydrogel-IL formulations exhibit enhanced stability following 120 days of storage under 4 °C compared to in phosphate buffered saline (PBS). Visual tests demonstrate that the CP of the micellar-IL carriers can be finely tuned (31- 46 °C). Rheology measurements show that hydrogel strength is significantly increased and Tgel is reduced, from 40 °C in PBS to 30 °C with IL. Finally, a unique stabilisation mechanism is proposed, triggered by the synergetic action of the excipients and IL in each system |
| Databáze: | OpenAIRE |
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