Probing spinal circuits controlling walking in mammals
| Autor: | Ole Kiehn, Kimberly J. Dougherty, Martin Hägglund, Carlos Ernesto Restrepo, Adolfo E. Talpalar, Lotta Borgius |
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| Rok vydání: | 2010 |
| Předmět: |
Motor Neurons
Neural substrate of locomotor central pattern generators in mammals Interneuron Biophysics Network structure Central pattern generator Rodentia Walking Cell Biology Anatomy Optogenetics Biology Spinal cord Biochemistry Electrophysiology Spinal circuits medicine.anatomical_structure Spinal Cord medicine Animals Muscle Skeletal Molecular Biology Neuroscience |
| Zdroj: | Biochemical and Biophysical Research Communications. 396:11-18 |
| ISSN: | 0006-291X |
| DOI: | 10.1016/j.bbrc.2010.02.107 |
| Popis: | Locomotion in mammals is a complex motor act that involves the activation of a large number of muscles in a well-coordinated pattern. Understanding the network organization of the intrinsic spinal networks that control the locomotion, the central pattern generators, has been a challenge to neuroscientists. However, experiments using the isolated rodent spinal cord and combining electrophysiology and molecular genetics to dissect the locomotor network have started to shed new light on the network structure. In the present review, we will discuss findings that have revealed the role of designated populations of neurons for the key network functions including coordinating muscle activity and generating rhythmic activity. These findings are summarized in proposed organizational principles for the mammalian segmental CPG. |
| Databáze: | OpenAIRE |
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