Changes in interleukin-6 levels during electroconvulsive therapy may reflect the therapeutic response in major depression
| Autor: | Kati Tuohimaa, Mari Hämäläinen, Kai Lehtimäki, Jukka Peltola, Kaija Järventausta, Esa Leinonen, Olli Kampman, Annamari Sorri, Eeva Moilanen, Minna Björkqvist |
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| Rok vydání: | 2016 |
| Předmět: |
Adult
Male medicine.medical_specialty Time Factors medicine.drug_class medicine.medical_treatment Interleukin-1beta behavioral disciplines and activities Proinflammatory cytokine 03 medical and health sciences 0302 clinical medicine Electroconvulsive therapy Rating scale Internal medicine mental disorders medicine Humans Electroconvulsive Therapy Psychiatry Interleukin 6 Depression (differential diagnoses) Aged Aged 80 and over Depressive Disorder Major biology Interleukin-6 Middle Aged medicine.disease Receptor antagonist 030227 psychiatry Interleukin 1 Receptor Antagonist Protein Psychiatry and Mental health Treatment Outcome Cytokine biology.protein Major depressive disorder Female Psychology 030217 neurology & neurosurgery |
| Zdroj: | Acta Psychiatrica Scandinavica. 135:87-92 |
| ISSN: | 0001-690X |
| Popis: | Objective Interleukin-6 (IL-6) has been reported to be elevated in major depressive disorder (MDD) but decreased by antidepressive medication. IL-6 levels are markedly elevated both after epileptic seizures and single electroconvulsive therapy (ECT) session, but long-term changes in IL-6 levels after ECT have not been studied. The correlation between immediate and long-term changes in proinflammatory cytokines and outcome after ECT was investigated. Method Thirty patients suffering from MDD participated in the study. IL-6, interleukin-1β (IL-1β) and interleukin-1 receptor antagonist (IL-1RA) levels were examined at baseline and at 2 and 4 h after the first, fifth and the last ECT sessions. The response to ECT was measured with Montgomery-Asberg Depression Rating Scale (MADRS). Results ECT repeatedly caused an increase in IL-6 levels at the 4-h time point. However, the baseline IL-6 levels decreased among remitters, but not among non-remitters, towards the end of ECT. IL-1β levels were mostly below detectable level, and IL-1Ra levels did not change during and after ECT. Conclusion ECT has distinct acute and long-term effects on IL-6 levels. Interestingly, the long-term effect of ECT on IL-6 seems to correlate with outcome, providing further evidence of the mechanism of action of ECT and supporting the inflammation theory in MDD. |
| Databáze: | OpenAIRE |
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