Fluorescent polymer cubosomes and hexosomes with aggregation-induced emission
| Autor: | Annie Brûlet, Nian Zhang, Bergam Ptissam, Yujiao Fan, Ben Zhong Tang, Min-Hui Li, Hui Chen, Sylvain Trépout |
|---|---|
| Přispěvatelé: | Institut de Recherche de Chimie Paris (IRCP), Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Ecole Nationale Supérieure de Chimie de Paris - Chimie ParisTech-PSL (ENSCP), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Ministère de la Culture (MC) |
| Rok vydání: | 2021 |
| Předmět: |
chemistry.chemical_classification
Materials science Small-angle X-ray scattering 02 engineering and technology General Chemistry Polymer 010402 general chemistry 021001 nanoscience & nanotechnology 01 natural sciences Fluorescence 0104 chemical sciences 3. Good health Chemistry Colloid chemistry Chemical engineering Amphiphile Copolymer [CHIM]Chemical Sciences Fluorescent polymer 0210 nano-technology Pendant group |
| Zdroj: | Chemical Science Chemical Science, The Royal Society of Chemistry, 2021, 12 (15), pp.5495-5504. ⟨10.1039/d1sc00270h⟩ |
| ISSN: | 2041-6539 2041-6520 |
| Popis: | Fluorescent polymer cubosomes and hexosomes with aggregation-induced emission (AIE) were prepared from amphiphilic block copolymers PEG-b-PTPEMA where the hydrophobic block PTPEMA was a polymethacrylate with tetraphenylethene (TPE) as the AIE side group. Four highly asymmetric block copolymers with hydrophilic block weight ratio fPEG ≤ 20% were synthesized. Cubosomes and hexosomes with strong fluorescence emission were obtained by nanoprecipitation of polymers with fPEG < 9% in dioxane/water and THF/water systems. Their ordered internal structures were studied by electron microscopy (cryo-EM, SEM and TEM) and the X-ray scattering technique (SAXS). To elucidate the formation mechanisms of these inverted colloids, other parameters influencing the morphologies, like the water content during self-assembly and the organic solvent composition, were also investigated. This study not only inspires people to design novel building blocks for the preparation of functional cubosomes and hexosomes, but also presents the first AIE fluorescent polymer cubosome and hexosome with potential applications in bio-related fields. Fluorescent Im3̄m cubosome and P6mm hexosome with aggregation-induced emission (AIE) were reported, which were formed by amphiphilic block copolymers PEG-b-PTPEMA. The length of hydrophobic block PTPEMA was adjusted to control morphology formation. |
| Databáze: | OpenAIRE |
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