Multiple Introductions Followed by Ongoing Community Spread of SARS-CoV-2 at One of the Largest Metropolitan Areas of Northeast Brazil

Autor: Michelle da Silva Barros, Armando de Menezes Neto, Elisama Helvecio, Rodrigo Moraes Loyo Arcoverde, Renata Pessôa Germano Mendes, Filipe Zimmer Dezordi, Tiago Gräf, Luydson Richardson Silva Vasconcelos, Severino Jefferson Ribeiro da Silva, Derciliano Lopes da Cruz, Larissa Krokovsky, Duschinka Ribeiro Duarte Guedes, Antonio Mauro Rezende, Gonzalo Bello, Claudio Eduardo Cavalcanti, Wheverton Ricardo Correia do Nascimento, Cássia Docena, Caroline Targino Alves da Silva, Maria Almerice Lopes da Silva, Gabriel Luz Wallau, Alexandre Freitas da Silva, Kamila Gaudêncio da Silva Sales, Marcelo Henrique Santos Paiva, Paola Cristina Resende, Luciane Caroline Albuquerque Bezerra, Constância Flávia Junqueira Ayres, Matheus Filgueira Bezerra, Sinval Pinto Brandão Filho, Laís Ceschini Machado, Bruna Santos Lima Figueiredo de Sá
Rok vydání: 2020
Předmět:
Zdroj: Viruses
Viruses; Volume 12; Issue 12; Pages: 1414
Viruses, Vol 12, Iss 1414, p 1414 (2020)
ISSN: 1999-4915
Popis: Multiple epicenters of the SARS-CoV-2 pandemic have emerged since the first pneumonia cases in Wuhan, China, such as Italy, USA, and Brazil. Brazil is the third-most affected country worldwide, but genomic sequences of SARS-CoV-2 strains are mostly restricted to states from the Southeast region. Pernambuco state, located in the Northeast region, is the sixth most affected Brazilian state, but very few genomic sequences from the strains circulating in this region are available. We sequenced 101 strains of SARS-CoV-2 from patients presenting Covid-19 symptoms that reside in Pernambuco. Phylogenetic reconstructions revealed that all genomes belong to the B lineage and most of the samples (88%) were classified as lineage B.1.1. We detected multiple viral introductions from abroad (likely from Europe) as well as six local B.1.1 clades composed by Pernambuco only strains. Local clades comprise sequences from the capital city (Recife) and other country-side cities, corroborating the community spread between different municipalities of the state. These findings demonstrate that different from Southeastern Brazilian states where the epidemics were majorly driven by one dominant lineage (B.1.1.28 or B.1.1.33), the early epidemic phase at the Pernambuco state was driven by multiple B.1.1 lineages seeded through both national and international traveling.
Databáze: OpenAIRE
Externí odkaz:
Nepřihlášeným uživatelům se plný text nezobrazuje