The prognostic significance of celiac lymph node metastasis in patients with locally advanced esophageal squamous cell carcinoma receiving curative concurrent chemoradiotherapy
| Autor: | Yu-Ming Wang, Su-Wei Chen, Shang-Yu Chou, Yen-Hao Chen, Chien-Ming Lo, Cheng-Hua Huang, Hung-I Lu, Li-Hsueh Shih, Shau-Hsuan Li |
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| Rok vydání: | 2017 |
| Předmět: |
celiac lymph node
squamous cell carcinoma 0301 basic medicine Oncology medicine.medical_specialty Celiac lymph nodes Locally advanced Metastasis concurrent chemoradiotherapy 03 medical and health sciences 0302 clinical medicine Internal medicine Medicine In patient esophageal cancer Stage (cooking) neoplasms Cancer staging business.industry nutritional and metabolic diseases Esophageal cancer medicine.disease digestive system diseases Surgery Concurrent chemoradiotherapy 030104 developmental biology medicine.anatomical_structure 030220 oncology & carcinogenesis business Research Paper |
| Zdroj: | Oncotarget |
| ISSN: | 1949-2553 |
| Popis: | // Yen-Hao Chen 1, 2, 3 , Hung-I Lu 4 , Yu-Ming Wang 5 , Chien-Ming Lo 4 , Shang-Yu Chou 5 , Cheng-Hua Huang 1 , Li-Hsueh Shih 6 , Su-Wei Chen 7 and Shau-Hsuan Li 1 1 Department of Hematology-Oncology, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan 2 Graduate Institute of Clinical Medical Sciences, College of Medicine, Chang Gung University, Taoyuan, Taiwan 3 School of Medicine, Chung Shan Medical University, Taichung, Taiwan 4 Department of Thoracic & Cardiovascular Surgery, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan 5 Department of Radiation Oncology, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan 6 Department of Nursing, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Taiwan 7 Department of Anesthesia, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan Correspondence to: Shau-Hsuan Li, email: lee.a0928@msa.hinet.net Keywords: celiac lymph node; esophageal cancer; squamous cell carcinoma; concurrent chemoradiotherapy Received: June 20, 2017 Accepted: September 23, 2017 Published: October 16, 2017 ABSTRACT Background: To evaluate the clinical outcomes of celiac lymph node (LN) metastasis in patients with locally advanced esophageal squamous cell carcinoma (ESCC) receiving curative concurrent chemoradiotherapy (CCRT). Materials and Methods: A total of 375 stage III ESCC patients were identified, including 51 patients with celiac LN metastasis and 324 patients without celiac LN metastasis. Among these 324 patients without celiac LN metastasis, 51 were matched with the 51 patients with celiac LN metastasis using the propensity score matching method. Results: Overall, the celiac LN metastasis group had worse progression-free survival (PFS) and overall survival (OS) than the non-celiac LN metastasis group and the matched non-celiac LN metastasis group. For the ESCC patients with celiac LN metastasis, lower third ESCC was significantly associated with superior PFS and OS. For patients with upper/middle third ESCC, the celiac LN metastasis group had worse PFS and OS than the non-celiac LN metastasis group and the matched non-celiac LN metastasis group. For patients with lower third ESCC, there were no significant differences in PFS and OS between these groups. Conclusions: Our study suggests celiac LN metastasis is a poor prognostic factor for locally advanced ESCC patients receiving curative CCRT. Among these ESCC patients with celiac LN metastasis, tumor location is a strongly prognostic factor, indicating patients with lower third ESCC have better PFS and OS than those with upper/middle third ESCC. The 6 th American Joint Committee on Cancer staging system seems more favorable than 7 th edition in the definition of celiac LNs for those patients. |
| Databáze: | OpenAIRE |
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