| Autor: |
Dr Priyanka Soni, Dr Ajitabh Soni, Dr Manoj Verma, Dr. Kusum Gaur |
| Jazyk: |
angličtina |
| Rok vydání: |
2018 |
| Předmět: |
|
| DOI: |
10.5281/zenodo.1324140 |
| Popis: |
— Schizophrenia is a neuro endocrinal diseases purticularly in volving Hypothalamic-pituitary-adrenal axis dysfunction, which has been widely researched in schizophrenia. Over activation of this axis is known to cause altered blood levels of cortisol and dehydroepiandrosterone sulfate (DHEA-S). Present study was conducted with the objective to compare serum levels of cortisol and dehydroepiandrosterone sulfate in schizophrenia patients and healthy control. A cross sectional case control observational study was conducted including 40 patients with first-episode schizophrenia along with 40 age and sex matched healthy controls. Patients were diagnosed as Schizophrenia according to ICD-10. Serum cortisol and DHEA-S were assessed in both groups. It was observed in this study that mean Serum level of DHEA-S was significantly (p< 0.001) higher in the Schizophrenia group (4320 ± 1120 µg/dL) as compared to control group (2760 ± 825 µg/dL), while cortisol level did not differ significantly between the two groups. It can be concluded from this study that the first-episode antipsychotic-naïve schizophrenic patients showed a significantly higher blood level of DHEA-S compared with healthy controls indicating role of DHEA-S in patho-physiology of schizophrenia. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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