The effect of desloratadine on ischemia reperfusion induced oxidative and inflammatory renal injury in rats
| Autor: | Mukadder Sunar, Gulce Naz Yazici, Mehmet Sefa Altay, Fevzi Bedir, Bahadir Suleyman, Halis Suleyman, Ebubekir Bakan, Hüseyin Kocatürk, Zeynep Suleyman |
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| Rok vydání: | 2020 |
| Předmět: |
Male
Interleukin-1beta 030232 urology & nephrology Ischemia ischemia Oxidative phosphorylation 030204 cardiovascular system & hematology Pharmacology Kidney lcsh:RC870-923 Critical Care and Intensive Care Medicine Cholinergic Antagonists Blood Urea Nitrogen 03 medical and health sciences 0302 clinical medicine Renal injury Malondialdehyde Laboratory Study Male rats medicine Animals rat cardiovascular diseases Rats Wistar Desloratadine Tumor Necrosis Factor-alpha urogenital system business.industry desloratadine NF-kappa B General Medicine Acute Kidney Injury Loratadine lcsh:Diseases of the genitourinary system. Urology medicine.disease Rats reperfusion Oxidative Stress medicine.anatomical_structure Nephrology Creatinine Reperfusion Injury renal business Research Article medicine.drug |
| Zdroj: | Renal Failure, Vol 42, Iss 1, Pp 531-538 (2020) Renal Failure article-version (VoR) Version of Record |
| ISSN: | 1525-6049 0886-022X |
| Popis: | Purpose To examine the effect of desloratadine on kidney ischemia-reperfusion (I/R) injury in albino Wistar male rats using biochemical and histopathological methods. Methods The treated with ischemia–reperfusion + 5 mg/kg desloratadine (IRD) group (n–6) was given 5 mg/kg desloratadine by gavage orally, and applied renal ischemia-reperfusion (BIR) group (n–6) and control (SG) group undergoing Sham operation (n–6) rats were given distilled water as solvent one hour before ketamine anesthesia. During the anesthesia period, ischemia was induced for 2 h unilaterally in the left kidney of all rats followed by reperfusion for 6 h. The kidneys of the SG group had sham operation without any intervention. Results Our biochemical test results showed that malondialdehyde (MDA), nuclear factor kappa (NF-κB), tumor necrosis factor alpha (TNF-α), interleukin one beta (IL-1β), creatinine, and blood urea nitrogen (BUN) levels were significantly increased in the BIR group compared to the healthy control and IRD groups treated with desloratadine. Histopathological results were revealed tubular dilatation, tubular necrosis, loss of brushy margins, cast formation, and apoptotic bodies in tubular epithelial cells in the BIR group. There were no histopathological findings except for the swelling of tubule epithelial cells and the accumulation of proteinous material in some tubule lumens in renal tissue of desloratadine-treated rats. Conclusions Experimental results suggested that desloratadine may be useful in the treatment of renal I/R injury. |
| Databáze: | OpenAIRE |
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