Anti-inflammatory effects of green soybean extract irradiated with visible light
| Autor: | Mamoru Isemura, Hiroyuki Ikemoto, Norio Ohashi, Keiko Tanaka, Shigeru Hiramoto, Yuki Katayanagi, Yasushi Ohgo, Yumi Nakata, Shinjiro Imai, Noriyuki Miyoshi, Kensuke Yasui |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
Interleukin 2
Chlorophyll b Male Light medicine.drug_class MAP Kinase Signaling System Anti-Inflammatory Agents Jurkat cells Anti-inflammatory Article Dermatitis Atopic chemistry.chemical_compound Jurkat Cells Mice medicine Animals Humans Multidisciplinary business.industry Plant Extracts Monocyte Daidzein Interleukin food and beverages Molecular biology Disease Models Animal medicine.anatomical_structure chemistry Immunology Interleukin 12 Cytokines Interleukin-2 Soybeans Inflammation Mediators business medicine.drug |
| Zdroj: | Scientific Reports |
| ISSN: | 2045-2322 |
| Popis: | We conducted a preliminary investigation of the effects of visible light irradiation on plant extracts and we observed a strong suppressive effect on interleukin (IL) 2 expression with the inhibition of c-Jun amino-terminal kinase (JNK) phosphorylation in Jurkat cells by visible light irradiation to ethanol extract from green soybeans (LIEGS). This effect was produced only by extracts from green soybeans (Glycine max) and not other-color soybeans. LIEGS suppressed the lipopolysaccharide-induced IL-6, IL-12 and TNF-α expression levels in human monocyte THP-1 cells in a concentration-dependent manner. LIEGS was applied for 8 weeks to NC/Nga mice. LIEGS suppressed the development of atopic dermatitis (AD)-like skin lesions and reduced the dermatitis scores of the mice. The light irradiation changed the various types of small-molecule compounds in extracts. Visible light irradiation to daidzein with chlorophyll b induced a novel oxidative product of daidzein. This product suppressed IL-2 expression in Jurkat cells. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|