Comparative analysis of glucoinsulinemic markers and proinflammatory cytokines in prepubertal children born large-versus appropriate-for gestational age
| Autor: | Feyza Darendeliler, Nurçin Saka, Ahmet Uçar, Rüveyde Bundak, Firdevs Bas, Ceren Çetin, Sukran Poyrazoglu |
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| Rok vydání: | 2014 |
| Předmět: |
Leptin
Male medicine.medical_specialty Endocrinology Diabetes and Metabolism Birth weight medicine.medical_treatment Adipokine Gestational Age Fetal Macrosomia Endocrinology Insulin resistance Diabetes mellitus Internal medicine medicine Birth Weight Humans Insulin-Like Growth Factor I Child Interleukin-6 Tumor Necrosis Factor-alpha business.industry Insulin Gestational age medicine.disease Obesity Insulin-Like Growth Factor Binding Protein 1 Cross-Sectional Studies Female Insulin Resistance business |
| Zdroj: | Endocrine. 47:816-824 |
| ISSN: | 1559-0100 1355-008X |
| DOI: | 10.1007/s12020-014-0207-0 |
| Popis: | Children born large for gestational age (LGA) may be at risk for development of obesity and insulin resistance (IR). The reciprocal relationship of adipokines and proinflammatory cytokines is suggested to play a putative role in fine tuning of insulin secretory dynamics. To evaluate serum interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), leptin, insulin-like growth factor-1 (IGF-1), and IGF-binding protein-1 (IGFBP-1) concentrations in idiopathic LGA-born children to appropriate for gestational age (AGA) and idiopathic LGA-born children at prepubertal ages and investigate their associations with IR, evaluated by homeostasis model assessment-IR (HOMA-IR), we conducted a cross-sectional study to compare 40 (19 females) idiopathic LGA-born prepubertal children [mean ± SD age 6.1 ± 2.5 years] and 49 (25 females) (5.4 ± 1.8 years) AGA-born BMI-matched peers with respect to anthropometric and laboratory data. Both groups were further divided into subgroups as being obese/overweight (OW) and non-OW, and the analyses were repeated. LGA-born children were taller and heavier than AGA-born children (p |
| Databáze: | OpenAIRE |
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