Episodic Memory Encoding and Retrieval in Face-Name Paired Paradigm: An fNIRS Study

Autor: Boris Cheval, Fabian Herold, Benjamin Becker, Notger Mueller, Liye Zou, Paul D. Loprinzi, Chetwyn C. H. Chan, Qian Yu, Yvonne Delevoye-Turrell, Ségolène M. R. Guérin
Přispěvatelé: Shenzhen University [Shenzhen], Université de Genève = University of Geneva (UNIGE), University of Electronic Science and Technology of China [Chengdu] (UESTC), Otto-von-Guericke-Universität Magdeburg = Otto-von-Guericke University [Magdeburg] (OVGU), German Research Center for Neurodegenerative Diseases - Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE), The Education University of Hong Kong (EdUHK), Laboratoire Sciences Cognitives et Sciences Affectives - UMR 9193 (SCALab), Université de Lille-Centre National de la Recherche Scientifique (CNRS), The University of Mississippi [Oxford], CHU Lille, CNRS, Université de Lille, University of Electronic Science and Technology of China [Chengdu] [UESTC], Otto-von-Guericke-Universität Magdeburg = Otto-von-Guericke University [Magdeburg] [OVGU], German Research Center for Neurodegenerative Diseases - Deutsches Zentrum für Neurodegenerative Erkrankungen [DZNE], The Education University of Hong Kong [EdUHK], 415060|||Sciences Cognitives et Sciences Affectives (SCALab) - UMR 9193 [SCALab], University of Geneva [Switzerland], University of Electronic Science and Technology of China (UESTC), Otto-von-Guericke University [Magdeburg] (OVGU), Sciences Cognitives et Sciences Affectives (SCALab) - UMR 9193 (SCALab)
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Zdroj: Brain Sciences
Volume 11
Issue 7
Brain Sciences, 2021, 11 (7), pp.951. ⟨10.3390/brainsci11070951⟩
Brain Sciences, Vol 11, Iss 951, p 951 (2021)
Brain Sciences, MDPI, 2021, 11 (7), pp.951. ⟨10.3390/brainsci11070951⟩
Brain Sciences 11(7), 951 (2021). doi:10.3390/brainsci11070951
ISSN: 2076-3425
DOI: 10.3390/brainsci11070951
Popis: Background. Early detection of process-specific episodic memory (EM) impairment can facilitate diagnostic accuracy and early intervention for aging and pathology related neurocognitive decline. Despite a high sensitivity of behavioral paradigms such as the paired-associate learning (PAL) paradigm, the determination of the underlying neurobiological dysregulations remains challenging. The present study was a first attempt to combine the PAL paradigm with functional near-infrared spectroscopy (fNIRS) to offer a method suitable to investigate Central and Autonomous Nervous System in more ecological and clinically contexts. Methods. Twenty-two male students (age: mean = 20.55, SD = 1.62) were included in this study and were asked to complete a PAL paradigm using faces. A 40-channel fNIRS system was used to measure relative changes in oxygenated hemoglobin in the bilateral prefrontal, superior parietal, inferior parietal, and middle occipital cortices. Changes were associated to different aspects of the paradigm, including memory phases, novelty, and difficulty level in face-name pairs. Results. Broad regions encompassing the bilateral frontal cortex (Brodmann area 1, 9, 11, 45, 46) were deactivated during encoding (FDR corrected p-values = 0.048, 0.012, 0.048, 0.048, 0.029), whereas a regional specific increase in the left orbitofrontal cortex (Brodmann area 11) was observed during retrieval (FDR corrected p-value = 0.048). The opposite brain responses of superior (increased HbO concentration compared to baseline) and inferior (decreased HbO concentration) parietal cortices were observed during encoding and the dominant activation of left PFC during retrieval. The higher paradigm difficult level was associated to greater beta value and HbO concentration in the bilateral prefrontal cortices; the higher novelty was found to generate greater occipital activation. Significant neurobio-behavioural correlations between the magnitude of brain activation (the right PFC) and behavioral performance (i.e., accuracy) during the retrieval process were also observed. Conclusion. The combination of a paired-associate learning paradigm with fNIRS provided the means to differentiate the two EM phases. Hence, fNIRS presents a promising technique to determine process-specific brain processes engaged in EM. This approach may provide a method for an early detection of EM deficits which, in turn, may allow for a timely onset of intervention counteracting EM decline.
Databáze: OpenAIRE
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