Immune cell phenotypes associated with disease severity and long-term neutralizing antibody titers after natural dengue virus infection
| Autor: | Danilo R. Casimiro, Tsin W. Yeo, Menaka Priyadharsani Rajapakse, Vanessa W. Lim, Bernett Lee, Laura Rivino, Amit Singhal, Bing Lim, Tun-Linn Thein, Thomas Loy, Melissa Hui Yen Chng, Durgalakshmi Sathiakumar, Kalpit A. Vora, Katja Fink, Lisa Tucker-Kellogg, Ying Xiu Toh, Angeline Rouers, Kaval Kaur, Yee Sin Leo, Evan W. Newell |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Serotype
Medicine (General) Plasma Cells T cells plasmablasts Dengue virus Cross Reactions medicine.disease_cause Antibodies Viral Serogroup General Biochemistry Genetics and Molecular Biology Article Dengue fever Time Immune system R5-920 Immunopathology medicine memory B cells Humans neutralizing antibodies Neutralizing antibody B cell B-Lymphocytes biology business.industry Antibody titer longitudinal study Dengue Virus medicine.disease dengue immune cell phenotype Antibodies Neutralizing medicine.anatomical_structure Phenotype Immunology biology.protein disease severity CyTOF business |
| Zdroj: | Cell Reports Medicine Cell Reports Medicine, Vol 2, Iss 5, Pp 100278-(2021) |
| ISSN: | 2666-3791 |
| Popis: | Summary Prior immunological exposure to dengue virus can be both protective and disease-enhancing during subsequent infections with different dengue virus serotypes. We provide here a systematic, longitudinal analysis of B cell, T cell, and antibody responses in the same patients. Antibody responses as well as T and B cell activation differentiate primary from secondary responses. Hospitalization is associated with lower frequencies of activated, terminally differentiated T cells and higher percentages of effector memory CD4 T cells. Patients with more severe disease tend to have higher percentages of plasmablasts. This does not translate into long-term antibody titers, since neutralizing titers after 6 months correlate with percentages of specific memory B cells, but not with acute plasmablast activation. Overall, our unbiased analysis reveals associations between cellular profiles and disease severity, opening opportunities to study immunopathology in dengue disease and the potential predictive value of these parameters. Graphical abstract Highlights T cell, B cell phenotypes, and antibodies are associated with dengue disease severity CXCR3+ CD8 T cell responses are associated with memory B cell formation Treg responses are associated with plasmablast responses Memory B cell numbers correlate with long-lasting neutralizing antibody titers Rouers et al. examine the phenotype of dengue immune responses in a longitudinal patient cohort and find associations between cellular profiles and disease severity. Immune cells that are associated with long-lasting neutralizing antibodies up to 1 year after disease onset are described. |
| Databáze: | OpenAIRE |
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