Clinical trial of CPT-11 and VM-26/VP-16 for patients with recurrent malignant brain tumors

Autor: Cristina Herrera, Carlos Robles, Niramol Savaraj, Deborah Heros, Howard J. Landy, Angela Marini, Arnold M. Markoe, Lynn G. Feun
Rok vydání: 2006
Předmět:
Zdroj: Journal of Neuro-Oncology. 82:177-181
ISSN: 1573-7373
0167-594X
DOI: 10.1007/s11060-006-9261-7
Popis: CPT-11 is a potent inhibitor of topoisomerase I and has shown antitumor activity in brain xenografts and in clinical trials in recurrent/progressive malignant glioma. VM-26 and VP-16 are topoisomerase II inhibitors and have also shown activity in phase II trials. We performed a phase II trial of intravenous CPT-11 (125 mg/m2) followed 24 h later by VM-26 (125 mg/m2). VP-16 (125 mg/m2) was later substituted for VM-26 due to drug shortage. For patients on anticonvulsants, the starting dose for all drugs was 150 mg/m2. Drugs were given weekly for 3 weeks followed by 1-week rest. Twenty-five patients were entered into the study. Three patients (12%) had improvement in CAT/MRI brain scans (95% confidence interval 3-31%). Fatigue and myelosuppression, mainly leukopenia, were the main toxicities. This combination of the topoisomerase I inhibitor CPT-11 followed by the topoisomerase II inhibitor, VM-26 or VP-16, has shown modest antitumor activity comparable to that reported for each drug singly. Myelosuppression is the main toxicity when topoisomerase I and II inhibitors are combined together.
Databáze: OpenAIRE
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