Lupus eritematoso neonatal: reporte de cuatro casos
| Autor: | Agustina Lanoël, Maria Eugenia de Torres, Andrea Bettina Cervini, Adrián M. Pierini, María Marta Buján, Maria Fernanda Perez |
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| Jazyk: | Spanish; Castilian |
| Rok vydání: | 2011 |
| Předmět: |
Pathology
medicine.medical_specialty Discoid lupus erythematosus business.industry Pediatría Transplacental Dermatology Maternal autoantibodies medicine.disease Congenital heart block Lupus eritematoso cutáneo immune system diseases medicine Cardiac defects Neonatal lupus erythematosus skin and connective tissue diseases business Cardiopatías Rare disease Anti-SSA/Ro autoantibodies |
| Zdroj: | Anais Brasileiros de Dermatologia v.86 n.2 2011 Anais brasileiros de dermatologia Sociedade Brasileira de Dermatologia (SBD) instacron:SBD |
| Popis: | Neonatal lupus erythematosus is a very rare disease, clinically characterized by skin lesions that resemble those of subacute or discoid lupus erythematosus and/or congenital heart block. Generally, when patients have skin manifestations, they have no cardiac defects and vice-versa; however, in 10% of cases these manifestations may coexist. Other findings may include hematologic, hepatic and neurological abnormalities. This condition is caused by the transplacental passage of maternal autoantibodies against Ro (95%), La and, less frequently, U1-ribonucleoprotein (U1-RNP). The present case report describes four patients with clinical, histopathological and immunological findings compatible with neonatal lupus erythematosus, their treatment and progress. |
| Databáze: | OpenAIRE |
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