Perinatal Exposure to Environmentally Relevant Levels of Bisphenol A Decreases Fertility and Fecundity in CD-1 Mice
| Autor: | Ana M. Soto, Michael H. Askenase, Perinaaz R. Wadia, Beverly S. Rubin, Gregory S. Whitt, Nicolas J. Cabaton, Carlos Sonnenschein, Andrew P. Tharp, Jennifer L. Gadbois, Daniel Zalko, Cheryl M. Schaeberle |
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| Přispěvatelé: | Métabolisme et Xénobiotiques (ToxAlim-MeX), ToxAlim (ToxAlim), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Ecole Nationale Vétérinaire de Toulouse (ENVT), Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Ecole d'Ingénieurs de Purpan (INPT - EI Purpan), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Recherche Agronomique (INRA)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Recherche Agronomique (INRA), Tufts University School of Medicine, Tufts University, National Institute of Environmental Health Sciences [ES08314] |
| Jazyk: | angličtina |
| Rok vydání: | 2011 |
| Předmět: |
Health
Toxicology and Mutagenesis bisphenol A [SDV]Life Sciences [q-bio] Uterus 010501 environmental sciences PROLACTIN-RELEASE 01 natural sciences chemistry.chemical_compound Mice BINDING media_common endocrine disruptor fertility 0303 health sciences Perinatal Exposure Reproduction Fecundity biphasic dose response medicine.anatomical_structure Endocrine disruptor Toxicity Environmental Pollutants Female MOUSE GENITAL-TRACT hormones hormone substitutes and hormone antagonists MALE REPRODUCTIVE HEALTH medicine.medical_specialty endocrine system media_common.quotation_subject fecundity ENDOCRINE-DISRUPTING CHEMICALS Ovary Fertility Biology perinatal exposure 03 medical and health sciences Phenols DIETHYLSTILBESTROL DES MAMMARY-GLAND Internal medicine fetal origins of adult disease PRENATAL EXPOSURE CD1 MICE CELLS medicine Animals Benzhydryl compounds Benzhydryl Compounds 030304 developmental biology 0105 earth and related environmental sciences Dose-Response Relationship Drug urogenital system Research Public Health Environmental and Occupational Health Endocrinology chemistry Animals Newborn |
| Zdroj: | Environmental Health Perspectives Environmental Health Perspectives, National Institute of Environmental Health Sciences, 2011, 119 (4), pp.547-552. ⟨10.1289/ehp.1002559⟩ Environmental Health Perspectives 4 (119), 547-552. (2011) |
| ISSN: | 0091-6765 1552-9924 |
| DOI: | 10.1289/ehp.1002559⟩ |
| Popis: | International audience; BACKGROUND: Perinatal exposure to low-doses of bisphenol A (BPA) results in alterations in the ovary, uterus, and mammary glands and in a sexually dimorphic region of the brain known to be important for estrous cyclicity. OBJECTIVES: We aimed to determine whether perinatal exposure to environmentally relevant doses of BPA alters reproductive capacity. METHODS: Female CD-1 mice that were exposed to BPA at 0, 25 ng, 250 ng, or 25 mu g/kg body weight (BW)/day or diethylstilbestrol (DES) at 10 ng/kg BW/day (positive control) from gestational day 8 through day 16 of lactation were continuously housed with proven breeder males for 32 weeks starting at 2 months of age. At each delivery, pups born to these mating pairs were removed. The cumulative number of pups, number of deliveries, and litter size were recorded. The purity of the BPA used in this and our previous studies was assessed using HPLC, mass spectrometry, and nuclear magnetic resonance. RESULTS: The forced breeding experiment revealed a decrease in the cumulative number of pups, observed as a non-monotonic dose-response effect, and a decline in fertility and fecundity over time in female mice exposed perinatally to BPA. The BPA was 97% pure, with no evidence of contamination by other phenolic compounds. CONCLUSIONS: Perinatal exposure to BPA leads to a dose-dependent decline in the reproductive capacity of female mice. The effects on the cumulative number of pups are comparable to those previously reported in mice developmentally exposed to DES, a compound well known to impair reproduction in women. This association suggests the possibility that early BPA exposure may also affect reproductive capacity in women. |
| Databáze: | OpenAIRE |
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