Enantioselective Synthesis of C-N Axially Chiral N-Aryloxindoles by Asymmetric Rhodium-Catalyzed Dual C-H Activation

Autor:	Jitan Zhang, Honghe Li, Ji-Jun Jiang, Xiaoqiang Yan, Weicong Guo, Jun Wang
Rok vydání:	2019
Předmět:	010405 organic chemistry Chemistry Stereochemistry Enantioselective synthesis chemistry.chemical_element General Chemistry General Medicine 010402 general chemistry 01 natural sciences Catalysis 0104 chemical sciences Rhodium Yield (chemistry) Axial symmetry
Zdroj:	Angewandte Chemie (International ed. in English). 58(20)
ISSN:	1521-3773
Popis:	The first enantioselective Satoh-Miura-type reaction is reported. A variety of C-N axially chiral N-aryloxindoles have been enantioselectively synthesized by an asymmetric rhodium-catalyzed dual C-H activation reaction of N-aryloxindoles and alkynes. High yields and enantioselectivities were obtained (up to 99 % yield and up to 99 % ee). To date, it is also the first example of the asymmetric synthesis of C-N axially chiral compounds by such a C-H activation strategy.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4381c946b96f8760d4d53cb0a0dc1b87 https://pubmed.ncbi.nlm.nih.gov/30893497 Zobrazit plný text záznamu Plný text