A meta-analysis of the efficiency of metal nanoparticles in vaccine delivery against infectious disease
| Autor: | Andrew J. Easton, Gholamreza Ahmadian, Fatemeh Ramezani, Zakieh Sadat Hoseini, Abbas Hajizade |
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| Rok vydání: | 2021 |
| Předmět: |
Oncology
medicine.medical_specialty medicine.medical_treatment Biomedical Engineering Metal Nanoparticles Medicine (miscellaneous) Bioengineering 02 engineering and technology Development Communicable Diseases 03 medical and health sciences Study Eligibility Criteria Adjuvants Immunologic Internal medicine medicine Animals General Materials Science Metal nanoparticles 030304 developmental biology Vaccines 0303 health sciences business.industry Vaccine delivery 021001 nanoscience & nanotechnology Infectious disease (medical specialty) Meta-analysis Gold 0210 nano-technology business Adjuvant |
| Zdroj: | Nanomedicine. 16:481-495 |
| ISSN: | 1748-6963 1743-5889 |
| Popis: | Background: Exploration of the efficiency of metal nanoparticles as adjuvants have reported varying results. Objective: The efficacy of metal nanoparticles as adjuvants was investigated Data sources: Database were searched using the terms ‘metal nanoparticles’ and ‘vaccines’. Study eligibility criteria: Studies in animal models utilizing any metal-based vaccines, where the survival rate was described. Study appraisal: The quality of the studies was examined using aspects of the ARRIVE guidelines and assessment of the risk of bias of included studies. Results: Metal nanoparticle-based adjuvants were more effective compared with control (unvaccinated groups) but have not been more successful in competing with common adjuvants or even antigens alone. Limitation: More than 75% of articles have used only gold nanoparticles. Conclusion: Nano-adjuvants do not have a significant effect on reducing mortality. |
| Databáze: | OpenAIRE |
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