Antitumor activity of Pogostemon benghalensis Linn. on ehrlich ascites carcinoma tumor bearing mice
| Autor: | Manish S. Patel, Raju Senthilkumar, Ena Dowerah, Mangala Lahkar, Bhavesh V Antala |
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| Rok vydání: | 2015 |
| Předmět: |
Pogostemon benghalensis
hook-loti Administration Oral India Pharmacology lcsh:RC254-282 Antioxidants Ehrlich ascites carcinoma Diffusion Mice Medicine Animals Radiology Nuclear Medicine and imaging Solid tumor Carcinoma Ehrlich Tumor Antitumor activity Ethanol business.industry median survival time Plant Extracts Carcinoma Intraperitoneal inoculation Cancer General Medicine medicine.disease lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens Antineoplastic Agents Phytogenic Treatment period Plant Leaves Oncology Immunology solid tumor Female Drug Screening Assays Antitumor business Median survival Neoplasm Transplantation Apiaceae Phytotherapy |
| Zdroj: | Journal of Cancer Research and Therapeutics, Vol 10, Iss 4, Pp 1071-1075 (2014) |
| ISSN: | 1998-4138 |
| Popis: | Background: Pogostemon benghalensis has been used traditionally as anticancer in India. Aim of the Study: The present study was undertaken to investigate the antitumor activity of hydroethanolic extract of P. benghalensis (HEEPB) and aqueous extract of P. benghalensis (AEPB) on ehrlich ascites carcinoma (EAC) tumor bearing mice. Materials and Methods: For antitumor effect, treatments with HEEPB and AEPB at doses of 250 mg/kg and 500 mg/kg/day orally were started after 24 h of intraperitoneal inoculation of EAC cells. After the treatment period, median survival time (MST), hematological parameters and solid tumor volume were used to evaluate antitumor activity of the extracts. Results: Both, HEEPB and AEPB, have increased MST (P < 0.05), reduced solid tumor volume (P < 0.05) and normalized hematological parameters (P < 0.05) significantly. Conclusion: As HEEPB and AEPB were effective in reducing the severity of morphological and biochemical parameters induced by EAC cells, this study justifies the traditional use of this plant in cancer. |
| Databáze: | OpenAIRE |
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