Traditional and Nontraditional Cardiovascular Risk Factors and Estimated Risk for Coronary Artery Disease in Renal Transplant Recipients: A Single-Center Experience
| Autor: | Miriam C. Banas, Stephan R. Orth, Stephan W. Reinhold, Bernhard Banas, Veronika Langer, Bernd Krüger, Christian Weingart, Bernhard K. Krämer, Bettina Jung |
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| Rok vydání: | 2011 |
| Předmět: |
Adult
Male medicine.medical_specialty Time Factors medicine.medical_treatment Hypercholesterolemia Population 610 Medizin Blood Pressure Coronary Artery Disease Coronary artery disease Bias Renal Dialysis Risk Factors Internal medicine Diabetes mellitus Diabetes Mellitus medicine Humans education Antihypertensive Agents Kidney transplantation Aged ddc:610 education.field_of_study Framingham Risk Score business.industry Smoking Age Factors Immunosuppression General Medicine Middle Aged medicine.disease Kidney Transplantation Transplantation Cholesterol Cross-Sectional Studies Nephrology Creatinine Hypertension Hypertension Smoking Hyperlipidemia Diabetes Risk factor control Immunosuppression Kidney transplantation Statins Cohort Cardiology Female business Immunosuppressive Agents |
| Zdroj: | Nephron Clinical Practice. 119:c227-c235 |
| ISSN: | 1660-2110 |
| DOI: | 10.1159/000327616 |
| Popis: | Background/Aims: The prevalence of cardiovascular disease in renal transplant recipients is markedly higher than in the general population due to the high prevalence of traditional cardiovascular risk factors, renal transplant function impairment and treatment with immunosuppressive drugs that affect blood pressure, cholesterol and blood glucose levels. Methods: Cross-sectional analysis using our renal transplant clinic cohort investigating (1) the cardiovascular risk factors present in this cohort, and (2) estimating their impact on the risk of coronary artery disease (CAD) by using the Framingham algorithm. Results: Control of modifiable cardiovascular risk factors in 231 renal transplant recipients is suboptimal, i.e. 47.2% of patients are hypertensive, 10.3% actively smoke, 39.4% have serum cholesterol concentrations >200 mg/dl, and 19.7% have diabetes mellitus. Blood pressure, age, hyperlipidemia, smoking and diabetes modulate the estimated CAD risk in males and females. Furthermore, a short time period (less than 1 year) since transplantation and increased serum creatinine levels negatively influenced the CAD risk in this patient population. Conclusion: According to current guidelines, the control of modifiable cardiovascular risk factors in renal transplant recipients is suboptimal. The decreasing CAD risk over time after transplantation may be due to the reduction of immunosuppressive drugs with time and survival bias. OA-Komponente aus Allianzlizenz |
| Databáze: | OpenAIRE |
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