C1q as a potential tolerogenic therapeutic in transplantation
| Autor: | William M. Baldwin, Robert L. Fairchild, Anna Valujskikh |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
chemical and pharmacologic phenomena
030230 surgery medicine.disease_cause Article Autoimmunity 03 medical and health sciences Classical complement pathway 0302 clinical medicine Immune system immune system diseases Immunology and Allergy Medicine Pharmacology (medical) skin and connective tissue diseases Antigen-presenting cell Complement Activation Transplantation Innate immune system Complement C1s Complement C1r business.industry Complement C1q Pattern recognition receptor Complement system Cell biology business |
| Zdroj: | Am J Transplant |
| ISSN: | 1600-6135 |
| Popis: | In 1963, Lepow and colleagues resolved C1, the first component of the classical pathway, into three components, which they named C1q, C1r, and C1s. All three of these components were demonstrated to be involved in causing hemolysis in vitro. For over 30 years after that seminal discovery, the primary function attributed to C1q was as part of the C1 complex that initiated the classical pathway of the complement cascade. Then, a series of papers reported that isolated C1q could bind to apoptotic cells and facilitate their clearance by macrophages. Since then, rheumatologists have recognized that C1q is an important pattern recognition receptor (PRR) that diverts autoantigen containing extracellular vesicles from immune recognition. This critical function of C1q as a regulator of immune recognition has been largely overlooked in transplantation. Now that extracellular vesicles released from transplants have been identified as a major agent of immune recognition, it is logical to consider the potential impact of C1q on modulating the delivery of allogeneic extracellular vesicles to antigen presenting cells. This concept has clinical implications in the possible use of C1q or a derivative as a biological therapeutic to down-modulate immune responses to transplants. |
| Databáze: | OpenAIRE |
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