Changes of the Sensory Abnormalities and Cortical Excitability in Patients with Complex Regional Pain Syndrome of the Upper Extremity After 6 Months of Multimodal Treatment
| Autor: | Annika Reinersmann, Christoph Maier, Martin Tegenthoff, Melanie Lenz, Elena K. Enax-Krumova, Jule Frettlöh, Andreas Schwarzer, Oliver Höffken, Andrea Westermann |
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| Rok vydání: | 2016 |
| Předmět: |
Adult
Male Pain Threshold Stimulation Sensory system Upper Extremity 03 medical and health sciences 0302 clinical medicine 030202 anesthesiology Evoked Potentials Somatosensory Threshold of pain medicine Humans Multimodal treatment Longitudinal Studies Aged business.industry General Medicine Middle Aged medicine.disease Combined Modality Therapy Median nerve Anesthesiology and Pain Medicine Complex regional pain syndrome Hyperalgesia Somatosensory evoked potential Anesthesia Cortical Excitability Female Neurology (clinical) medicine.symptom business Complex Regional Pain Syndromes 030217 neurology & neurosurgery |
| Zdroj: | Pain Medicine. 18:95-106 |
| ISSN: | 1526-4637 1526-2375 |
| DOI: | 10.1093/pm/pnw147 |
| Popis: | Objective. The most prominent sensory sign of the complex regional pain syndrome (CRPS) is blunt hyperalgesia, but longitudinal studies on its relation to the outcome of long-term multimodal treatment are lacking. Methods. We examined 24 patients with CRPS type I using standardized Quantitative Sensory Testing on the affected hand and the contralateral hand at baseline and 6 months following treatment. Somatosensory evoked potentials after single and paired-pulse stimulation of the median nerve were performed to assess the paired-pulse suppression (n = 19). Treatment response at follow-up was defined as pain relief > 30% and improved hand function. Statistics: Wilcoxon test, Pearson correlation. Results. At baseline, similar to previous studies, the pressure pain threshold (PPT) was significantly decreased and the pain response to repeated pinprick stimuli was significantly increased, while all detection thresholds were within the normal range without any difference between the later treatment responders and non-responders. After 6 months of treatment, the PPT increased significantly in the whole study group. However, the pressure hyperalgesia improved only in treatment responders (n = 17, P |
| Databáze: | OpenAIRE |
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