Human eosinophils modulate peripheral blood mononuclear cell response to Schistosoma mansoni adult worm antigen in vitro
| Autor: | Tweyongyere, R, Namanya, H, Naniima, P, Cose, S, Tukahebwa, EM, Elliott, AM, Dunne, DW, Wilson, S |
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| Přispěvatelé: | Dunne, David [0000-0002-8940-9886], Wilson, Shona [0000-0001-5725-4376], Apollo - University of Cambridge Repository |
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
Adult
immune modulation Interleukin-13 Tumor Necrosis Factor-alpha Brief Definitive Report Schistosoma mansoni cytokines Schistosomiasis mansoni Interleukin-10 Eosinophils Interferon-gamma schistosomiasis Antigens Helminth Leukocytes Mononuclear Brief Definitive Reports Animals Humans Interleukin-4 Interleukin-5 Cells Cultured |
| Zdroj: | Parasite Immunology |
| ISSN: | 0141-9838 |
| Popis: | Summary High numbers of eosinophils are observed in parasitic infections and allergic diseases, where they are proposed to be terminally differentiated effector cells that play beneficial role in host defence, or cause harmful inflammatory response. Eosinophils have been associated with killing of schistosomulae in vitro, but there is growing evidence that eosinophils can play additional immuno‐regulatory role. Here, we report results of a study that examines peripheral blood mononuclear cell (PBMC) cytokine responses to Schistosoma mansoni adult worm antigen (SWA) when stimulated alone or enriched with autologous eosinophils. Production of the Th‐2 type cytokines interleukin (IL)‐4, IL‐5 and IL‐13 was lower (P = 0·017, 0·018 and |
| Databáze: | OpenAIRE |
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