Elevated serum uric acid reduce heart damage in patients undergoing open-heart surgery
| Autor: | A. Nikolic, D. Mijalkovic, D. Kastratovic, D. Blagojevic, B. Davidovic, M. Spasic |
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| Rok vydání: | 2006 |
| Předmět: |
Male
medicine.medical_specialty antioksidanti creatin phosphokinase mokraćna kiselina Carbazoles Ischemia Myocardial Reperfusion Injury Antioxidants Propanolamines chemistry.chemical_compound uric acid cardiovascular disease oksidativni stres medicine Humans oxidative stress Coronary Artery Bypass Creatine Kinase Carvedilol Aged biology business.industry Extracorporeal circulation oboljenja kardiovaskularnog sistema EuroSCORE General Medicine Middle Aged medicine.disease Uric Acid Surgery antioxidants chemistry kreatin fosfokinaza biology.protein Uric acid Creatine kinase business Reperfusion injury Peroxynitrite medicine.drug |
| Zdroj: | Acta chirurgica iugoslavica |
| ISSN: | 2406-0887 0354-950X |
| DOI: | 10.2298/aci0603029n |
| Popis: | Objectives: Peroxynitrite is species claimed to propagate ischemia/reperfusion damage. In this report levels of serum uric acid (UA), a peroxynitrite scavenger, are compared with creatine phosphokinase (CPK) in male patients before and after open-heart surgery in order to asses if increased levels of UA may protect heart from biochemical damage induced by peroxynitrite during the coronary by-pass grafting (CABG) intervention. Methods: 45 male patients (16 carvedilol pretreated (6.25 mg/ daily, during 6 weeks before surgery, mean age 55.3±1.7 years, range 50-71) and 29 patients without carvedilol pretreatment (mean age 58.3±1.4 years, range 47-73) underwent elective CABG were examined. Study inclusion criteria were CABG performed on two and more coronary-vessels with aortic crossclamp during 30-40 minutes. For assessment of patients objective health status before operations Euro- SCORE were used. Serum uric acid (UA) levels and creatine phosphokinase (CPK) were measured spectrophotometricaly by using a quantitative enzymatic assay. Results: Carvedilol pretreated patients had higher amount of serum UA (p |
| Databáze: | OpenAIRE |
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