Plant Phenolics as Pathogen-Carrier Immunogenicity Modulator Haptens
| Autor: | Vega-Menchaca María-Del-Carmen, Serrano-Gallardo Luis-Benjamín, Delgadillo-Guzmán Dealmy, Cabral-Hipólito Nidia, Rivera-Guillén Mario-Alberto, Pedroza-Escobar David, Sevilla-González María-de-la-Luz, Castillo-Maldonado Irais, Ramírez-Moreno Agustina |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Immunogen Pharmaceutical Science Antigen-Presenting Cells pathogen-carrier immunogenicity Adaptive Immunity Epitope Article 03 medical and health sciences 0302 clinical medicine Immune system Phenols Animals Humans Amino Acids Pathogen chemistry.chemical_classification toleragen Chemistry haptens Immunogenicity Plants Immunity Innate Amino acid immunogen 030104 developmental biology Biochemistry 030220 oncology & carcinogenesis Host-Pathogen Interactions Signal transduction Hapten Plant phenolics Biotechnology Signal Transduction |
| Zdroj: | Current Pharmaceutical Biotechnology |
| ISSN: | 1873-4316 1389-2010 |
| Popis: | Background: Pathogens use multiple mechanisms to disrupt cell functioning in their host and allow pathogenesis. These mechanisms involve communication between the pathogen and the host cell through protein-protein interactions. Methods: Protein-protein interactions chains referred to as signal transduction pathways are the processes by which a chemical or physical signal transmits through a cell as series of molecular events so the pathogen needs to intercept these molecular pathways at few positions to induce pathogenesis such as pathogen viability, infection or hypersensitivity. Results: The pathogen nodes of interception are not necessarily the most immunogenic; so that novel immunogenicity-improvement strategies need to be developed thought a chemical conjugation of the pathogen-carrier nodes to develop an efficient immune response in order to block pathogenesis. On the other hand, if pathogen-carriers are immunogens; toleration ought to be induced by this conjugation avoiding hypersensitivity. Thus, this paper addresses the biological plausibility of plant-phenolics as pathogen-carrier immunogenicity modulator haptens. Conclusion: The plant-phenolic compounds have in their structure functional groups such as hydroxyl, carbonyl, carboxyl, ester, or ether, capable of reacting with the amino or carbonyl groups of the amino acids of a pathogen-carrier to form conjugates. Besides, the varied carbon structures these phenolic compounds have; it is possible to alter the pathogen-carrier related factors that determine the immunogenicity: 1) Structural complexity, 2) Molecular size, 3) Structural heterogeneity, 4) Accessibility to antigenic determinants or epitopes, 5) Optical configuration, 6) Physical state, or 7) Molecular rigidity. |
| Databáze: | OpenAIRE |
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