The effect of quercetin-3-O-β-D-glucuronopyranoside on indomethacin-induced gastric damage in rats via induction of mucus secretion and down-regulation of ICAM-1 expression
| Autor: | Chaeuk Im, Hak Rim Kim, Xiang Mei Yan, Wan Kyun Whang, Min Jae Joo, Sang Soo Sim, Uy Dong Sohn, Inkyeom Kim, Jae Chun Lim, Seok-Yong Lee |
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| Rok vydání: | 2010 |
| Předmět: |
Male
medicine.medical_treatment Blotting Western Indomethacin Interleukin-1beta Rats Sprague-Dawley Downregulation and upregulation Drug Discovery Gastric mucosa medicine Animals Secretion Stomach Ulcer Rumex Peroxidase biology Tumor Necrosis Factor-alpha Organic Chemistry biochemical phenomena metabolism and nutrition Intercellular adhesion molecule Anti-Ulcer Agents Intercellular Adhesion Molecule-1 Mucus Molecular biology Rats Plant Leaves medicine.anatomical_structure Cytokine Gastric Mucosa Myeloperoxidase Gastritis Immunology biology.protein Molecular Medicine Tumor necrosis factor alpha Quercetin |
| Zdroj: | Archives of pharmacal research. 34(9) |
| ISSN: | 1976-3786 |
| Popis: | The mechanism of the protective effect of quercetin-3-O-β-D-glucuronopyranoside (QGC) from the leaves of Rumex aqauticus on indomethacin (IND, a representative NSAID)-induced gastric damage in rats was investigated. Pre-treatment with QGC significantly attenuated IND-induced gastric mucosal injury. An increase in myeloperoxidase (MPO) activity and expression of intercellular adhesion molecule (ICAM)-1 protein and mRNA expression of the pro-inflammatory cytokines tumor necrosis factor-α and interleukin-1β, as well as a decrease in gastric mucus secretion were detected in the gastric mucosa of IND-treated rats. QGC reversed the side effect of IND on MPO activity and mucus production. Furthermore, QGC pre-treatment notably decreased ICAM-1 protein and mRNA expression of the pro-inflammatory cytokines, suggesting that QGC protection from IND-induced damage is associated with increased gastric mucus secretion, inhibition of free radical production by activated neutrophils via ICAM-1, and pro-inflammatory cytokine downregulation. |
| Databáze: | OpenAIRE |
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