Muscle Mass Assessed by Computed Tomography at the Third Lumbar Vertebra Predicts Patient Survival in Chronic Kidney Disease
| Autor: | Nivaldo Barroso de Pinho, N.C.S. Souza, Juliana Giglio, Celso Amodeo, Antonio C. Cordeiro, Fernanda C. Amparo, Maria Ayako Kamimura, Bengt Lindholm, Carla Maria Avesani, Peter Stenvinkel, Andre Valente Bichels, Juan Jesus Carrero |
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| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Male medicine.medical_specialty Percentile 030232 urology & nephrology Medicine (miscellaneous) Renal function 03 medical and health sciences 0302 clinical medicine Internal medicine medicine Humans Prospective Studies Renal Insufficiency Chronic Cause of death 030109 nutrition & dietetics Nutrition and Dietetics Lumbar Vertebrae Proportional hazards model business.industry Muscles Hazard ratio medicine.disease Prognosis Confidence interval Nephrology Cardiology Female business Tomography X-Ray Computed Cohort study Kidney disease |
| Zdroj: | Journal of renal nutrition : the official journal of the Council on Renal Nutrition of the National Kidney Foundation. 31(4) |
| ISSN: | 1532-8503 |
| Popis: | Objective Muscle mass is a key element for the evaluation of nutritional disturbances in patients with chronic kidney disease (CKD). Low muscle mass is associated with increased morbidity and mortality. The assessment of muscle mass by computed tomography at the third lumbar vertebra region (CTMM-L3) is an accurate method not subject to errors from fluctuation in the hydration status. Therefore, we aimed at investigating whether CTMM-L3 was able to predict mortality in nondialyzed CKD 3-5 patients. Methods This is a prospective observational cohort study. We evaluated 223 nondialyzed CKD patients (60.3 ± 10.6 years; 64% men; 50% diabetics; glomerular filtration rate 20.7 ± 9.6 mLmin1.73 m2). Muscle mass was measured by CTMM-L3 using the Slice-O-Matic software and analyzed according to percentile adjusted by gender. Nutritional parameters, laboratory data, and comorbidities were evaluated, and mortality was followed up for 4 years. Results During the study period, 63 patients died, and the main cause of death was cardiovascular disease. Patients who died were older, had lower hemoglobin and albumin, as well as lower muscle markers. CTMM-L3 below the 25th percentile was associated with higher mortality according to the Kaplan-Meier curve (P = .017) and in Cox regression analysis (crude hazard ratio, 1.87 [95% confidence interval, 1.11-3.16]), also when adjusting for potential confounders (hazard ratio 1.83 [95% confidence interval 1.02-3.30]). Conclusion Low muscle mass measured by computed tomography at the third lumbar vertebra region is an independent predictor of increased mortality in nondialyzed CKD patients. |
| Databáze: | OpenAIRE |
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