Antibacterial activity of T-5575, a novel 2-carboxypenam, and its stability to beta-lactamase
| Autor: | N Matsumura, Susumu Mitsuhashi, Shinzaburo Minami |
|---|---|
| Rok vydání: | 1997 |
| Předmět: |
Microbiology (medical)
Imipenem medicine.medical_treatment Ceftazidime beta-Lactams medicine.disease_cause beta-Lactamases Microbiology Gram-Negative Bacteria medicine Pharmacology (medical) Antibacterial agent Pharmacology biology Pseudomonas aeruginosa Hydrolysis Drug Resistance Microbial biology.organism_classification Anti-Bacterial Agents Cephalosporins Citrobacter freundii Kinetics Infectious Diseases Carbapenems Mutation Beta-lactamase Antibacterial activity Enterobacter cloacae medicine.drug |
| Zdroj: | Journal of Antimicrobial Chemotherapy. 39:31-34 |
| ISSN: | 1460-2091 |
| DOI: | 10.1093/jac/39.1.31 |
| Popis: | The in-vitro activity of T-5575, 2-carboxypenam, a new parenteral antibiotic and its stability to beta-lactamases were compared with those of ceftazidime and imipenem. The activity of T-5575 was equal or superior to that of ceftazidime or imipenem against Gram-negative bacteria that produced penicillinase with the exception of the enzyme OXA-1. Against strains that produced Cephalosporinase and zinc-dependent beta-lactamase, the activity of T-5575 was superior to that of ceftazidime or imipenem. T-5575 was a poor substrate and had low affinity for beta-lactamases produced by Citrobacter freundii, Enterobacter cloacae and Pseudomonas aeruginosa. The activity of T-5575 was less influenced by the derepressed production of chromosomal enzymes than that of ceftazidime. Overall, T-5575 had excellent activity against Gram-negative pathogens that produced various types of beta-lactamases. |
| Databáze: | OpenAIRE |
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