Lordosis facilitation by LHRH, PGE2 or db-cAMP requires activation of the kinase A signaling pathway in estrogen primed rats
| Autor: | Oscar González-Flores, Francisco Javier Lima-Hernández, Marcos García-Juárez, Carlos Beyer, Juan Manuel Ramírez-Orduña |
|---|---|
| Rok vydání: | 2007 |
| Předmět: |
endocrine system
medicine.medical_specialty medicine.drug_class Ovariectomy Posture Clinical Biochemistry Proceptive phase Gonadotropin-releasing hormone Biology Toxicology Biochemistry Dinoprostone Gonadotropin-Releasing Hormone Sexual Behavior Animal Behavioral Neuroscience chemistry.chemical_compound Oxytocics Internal medicine Cyclic AMP medicine Animals Biological Psychiatry Injections Intraventricular Pharmacology Estrous cycle Dose-Response Relationship Drug Estradiol Estrogens Fertility Agents Female Thionucleotides Cyclic AMP-Dependent Protein Kinases Rats Endocrinology Bucladesine chemistry Estrogen Estradiol benzoate Ovariectomized rat Female Luteinizing hormone hormones hormone substitutes and hormone antagonists Signal Transduction Hormone |
| Zdroj: | Pharmacology Biochemistry and Behavior. 86:169-175 |
| ISSN: | 0091-3057 |
| Popis: | Dose-response curves for lordosis and proceptive behaviors were obtained for luteinizing hormone releasing hormone (LHRH), prostaglandin E2 (PGE2) and dibutyryl cyclic AMP (db-cAMP), by infusing them in the right lateral ventricle (i.c.v.) of ovariectomized (OVX) estradiol benzoate (E2B; 2 microg) treated rats. Two dose levels, one producing the maximal effect and the other one producing a submaximal response (approximately ED50) were selected for testing the capacity of Rp-cAMPS, a kinase A blocker, to modify the behavioral response to the three compounds. I.c.v. injections of Rp-cAMPS, significantly depressed both lordosis and proceptive responses induced by LHRH, PGE2 and db-cAMP. The results show that these agents use the cAMP-kinase A signaling pathway to elicit their stimulating effect on estrous behavior in the rat. |
| Databáze: | OpenAIRE |
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