Characteristics and Outcomes in Patients With COVID-19 and Acute Ischemic Stroke
| Autor: | Arvind Chandratheva, George Ntaios, Per Meden, Michael V. Mazya, Tiago Moreira, Gheorghe Andrei Dan, Fabio Bandini, Eleni Korompoki, María Alonso de Leciñana, Guillaume Turc, Antonio Gil-Núñez, Jukka Putaala, Marjaana Tiainen, Paulo F. Castañeda-Méndez, Fernando Ostos, Stavropoula Tjoumakaris, Jaume Roquer, Robert Simister, Bernd Lamprecht, Alicia DeFelipe, Milan R. Vosko, Carlo W. Cereda, Andrés García-Pastor, Helle K. Iversen, Cristina Tiu, Luis Enrique Soto-Ramírez, Fernando Díaz-Otero, Alejandra González-Duarte, Martin W. Dünser, Louisa M. Christensen, Jaime Masjuan, Laura A Benjamin, Richard J. Perry, Ángel Basilio Corredor Quintero, David J. Werring, Roxana Vezeteu, Espen Saxhaug Kristoffersen, Ángela Rodríguez-López, Patricia Calleja, Errikos Maslias, Hanne Christensen, Antonio Arauz, Guillermo González-Ortega, Daniel Strbian, Elisa Cuadrado-Godia, Eduardo Soriano-Navarro, Wencheng Li, Patrik Michel, Blanca Fuentes, Julia Ferrari, Jing Xiong, Rahma Beyrouti, Exuperio Díez-Tejedor, Gregory Y.H. Lip, Helmut J. F. Salzer, Daniela Bay-Sansores, Lejla Hajdarevic, Yutao Guo, Vanessa Cano-Nigenda, Sebastián García-Madrona, Valerie Domigo, Ana Rodríguez Campello, Pascal Jabbour, Georgios Georgiopoulos, Bruno Gonçalves, Davide Strambo, Ahmad Sweid, Karl Matz |
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| Přispěvatelé: | University of Thessaly [Larissa], Université de Lausanne (UNIL), King‘s College London, Chinese PLA General Hospital, Huazhong University of Science & Technology, Instituto de Investigación Hospital Universitario 12 de Octubre, Doce de Octubre University Hospital, La Paz University Hospital, IdiPAZ Health Research Institute, Ramon & Cajal University Hospital, IRYCIS Health Research Institute, GHU Paris Psychiatrie et Neurosciences, Institut de psychiatrie et neurosciences de Paris (IPNP - U1266 Inserm), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Paris (UP), Paulo Niemeyer State Brain Institute, Colentina University Hospital, University of Medicine and Pharmacy 'Carol Davila' Bucharest (UMPCD), Bispebjerg Hospital, University of Copenhagen = Københavns Universitet (KU), Hospital General Universitario 'Gregorio Marañón' [Madrid], UCL Institute of Neurology, Queen Square, London, Thomas Jefferson University Hospitals, IMIM-Hospital del Mar, Generalitat de Catalunya, Universitat Autònoma de Barcelona (UAB), Universitat Pompeu Fabra [Barcelona] (UPF), Karolinska Institutet [Stockholm], San Paolo Hospital [Savona], Donau-Universität Krems, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán - National Institute of Medical Science and Nutrition Salvador Zubiran [Mexico], University Emergency Hospital [Bucharest], Kepler University Hospital, Johannes Kepler Universität Linz (JKU), Stroke Center EOC, Neurocenter of Southern Switzerland, Hospital Departamental Universitario del Quindío San Juan de DiosArmenia, National and Kapodistrian University of Athens (NKUA), Fundación Clínica Médica Sur [Mexico City], Instituto Nacional de Neurologia y Neurocirugia Manuel Velasco Suarez [Mexico], Akershus University Hospital [Lørenskog], University of Oslo (UiO), Helsinki University Hospital, University of Liverpool, Liverpool Heart & Chest Hospital, Aalborg University [Denmark] (AAU), Université de Lausanne = University of Lausanne (UNIL), Huazhong University of Science and Technology [Wuhan] (HUST), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité), University of Copenhagen = Københavns Universitet (UCPH), Martinez Rico, Clara |
| Rok vydání: | 2020 |
| Předmět: |
Male
Coronavirus Infections/complications coronavirus 030204 cardiovascular system & hematology Brain Ischemia Cohort Studies Disability Evaluation Brain Ischemia/complications 0302 clinical medicine Interquartile range Medicine Registries 10. No inequality Stroke Aged 80 and over education.field_of_study [SDV.MHEP] Life Sciences [q-bio]/Human health and pathology survivors Middle Aged 3. Good health Treatment Outcome Cohort ComputingMethodologies_DOCUMENTANDTEXTPROCESSING Female Coronavirus Infections Cardiology and Cardiovascular Medicine Cohort study medicine.medical_specialty Pneumonia Viral Population Time-to-Treatment 03 medical and health sciences Internal medicine Humans Propensity Score education Special Report Pandemics propensity score Survival analysis Aged Advanced and Specialized Nursing business.industry COVID-19 Recovery of Function Odds ratio medicine.disease Survival Analysis Brain Ischemia/diagnostic imaging Brain Ischemia/therapy Coronavirus Infections/diagnostic imaging Coronavirus Infections/therapy Pneumonia Viral/complications Pneumonia Viral/diagnostic imaging Pneumonia Viral/therapy Stroke/complications Stroke/diagnostic imaging Stroke/therapy Tomography X-Ray Computed prognosis Propensity score matching Neurology (clinical) business [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology 030217 neurology & neurosurgery |
| Zdroj: | Ntaios, G, Michel, P, Georgiopoulos, G, Guo, Y, Li, W, Xiong, J, Calleja, P, Ostos, F, González-Ortega, G, Fuentes, B, Alonso de Leciñana, M, Díez-Tejedor, E, García-Madrona, S, Masjuan, J, DeFelipe, A, Turc, G, Gonçalves, B, Domigo, V, Dan, G-A, Vezeteu, R, Christensen, H, Christensen, L M, Meden, P, Hajdarevic, L, Rodriguez-Lopez, A, Díaz-Otero, F, García-Pastor, A, Gil-Nuñez, A, Maslias, E, Strambo, D, Werring, D J, Chandratheva, A, Benjamin, L, Simister, R, Perry, R, Beyrouti, R, Jabbour, P, Sweid, A, Tjoumakaris, S, Cuadrado-Godia, E, Campello, A R, Roquer, J, Moreira, T, Mazya, M V, Bandini, F, Matz, K, Iversen, H K, González-Duarte, A, Tiu, C, Ferrari, J, Vosko, M R, Salzer, H J F, Lamprecht, B, Dünser, M W, Cereda, C W, Quintero, Á B C, Korompoki, E, Soriano-Navarro, E, Soto-Ramírez, L E, Castañeda-Méndez, P F, Bay-Sansores, D, Arauz, A, Cano-Nigenda, V, Kristoffersen, E S, Tiainen, M, Strbian, D, Putaala, J & Lip, G Y H 2020, ' Characteristics and Outcomes in Patients With COVID-19 and Acute Ischemic Stroke : The Global COVID-19 Stroke Registry ', Stroke, vol. 51, no. 9, pp. e254-e258 . https://doi.org/10.1161/STROKEAHA.120.031208 Stroke Stroke, American Heart Association, 2020, 51 (9), pp.e254-e258. ⟨10.1161/STROKEAHA.120.031208⟩ STROKE Stroke, vol. 51, no. 9, pp. e254-e258 |
| ISSN: | 1524-4628 0039-2499 |
| DOI: | 10.1161/strokeaha.120.031208 |
| Popis: | Supplemental Digital Content is available in the text. Recent case-series of small size implied a pathophysiological association between coronavirus disease 2019 (COVID-19) and severe large-vessel acute ischemic stroke. Given that severe strokes are typically associated with poor prognosis and can be very efficiently treated with recanalization techniques, confirmation of this putative association is urgently warranted in a large representative patient cohort to alert stroke clinicians, and inform pre- and in-hospital acute stroke patient pathways. We pooled all consecutive patients hospitalized with laboratory-confirmed COVID-19 and acute ischemic stroke in 28 sites from 16 countries. To assess whether stroke severity and outcomes (assessed at discharge or at the latest assessment for those patients still hospitalized) in patients with acute ischemic stroke are different between patients with COVID-19 and non-COVID-19, we performed 1:1 propensity score matching analyses of our COVID-19 patients with non-COVID-19 patients registered in the Acute Stroke Registry and Analysis of Lausanne Registry between 2003 and 2019. Between January 27, 2020, and May 19, 2020, 174 patients (median age 71.2 years; 37.9% females) with COVID-19 and acute ischemic stroke were hospitalized (median of 12 patients per site). The median National Institute of Health Stroke Scale was 10 (interquartile range [IQR], 4–18). In the 1:1 matched sample of 336 patients with COVID-19 and non-COVID-19, the median National Institute of Health Stroke Scale was higher in patients with COVID-19 (10 [IQR, 4–18] versus 6 [IQR, 3–14]), P=0.03; (odds ratio, 1.69 [95% CI, 1.08–2.65] for higher National Institute of Health Stroke Scale score). There were 48 (27.6%) deaths, of which 22 were attributed to COVID-19 and 26 to stroke. Among 96 survivors with available information about disability status, 49 (51%) had severe disability at discharge. In the propensity score-matched population (n=330), patients with COVID-19 had higher risk for severe disability (median mRS 4 [IQR, 2–6] versus 2 [IQR, 1–4], P |
| Databáze: | OpenAIRE |
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