Ru(II) Complexes of N-Alkylated TsDPEN Ligands in Asymmetric Transfer Hydrogenation of Ketones and Imines

Autor:	Jose E. D. Martins, Martin Wills, Guy J. Clarkson
Rok vydání:	2009
Předmět:	chemistry.chemical_classification Stereochemistry Organic Chemistry Imine Noyori asymmetric hydrogenation Crystal structure Alkylation Transfer hydrogenation Biochemistry Medicinal chemistry Catalysis chemistry.chemical_compound chemistry Physical and Theoretical Chemistry Enantiomer Alkyl
Zdroj:	Organic Letters. 11:847-850
ISSN:	1523-7052 1523-7060
DOI:	10.1021/ol802801p
Popis:	N-Alkylated TsDPEN derivatives bearing a small alkyl group act as highly efficient ligands in Ru(II) complexes for the asymmetric transfer hydrogenation of imines and ketones. A larger alkyl group serves to significantly reduce the activity of the catalyst; however, high enantiomeric excesses are still obtained. An X-ray crystal structure of the N-benzyl derivative reveals a conformation that permits hydrogen transfer through a six-membered transition state. A transition state structure for the imine reduction process is proposed.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4376227c0276e8d9d2873555270f1e6d https://doi.org/10.1021/ol802801p Zobrazit plný text záznamu