Pericardial effusion post-SCT in pediatric recipients with signs and/or symptoms of cardiac disease
| Autor: | Mitchell S. Cairo, Joseph E. Schwartz, C. van de Ven, C. Kleinman, M.B. Bradley, Prakash Satwani, James Garvin, D. George, Michelle Neier, Monica Bhatia, Eric S. Silver, Erin Morris, Zhezhen Jin, L. Baldinger |
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| Rok vydání: | 2010 |
| Předmět: |
medicine.medical_specialty
Transplantation Conditioning Heart Diseases Population Transplantation Autologous Pericardial effusion Pericardial Effusion Risk Factors immune system diseases Internal medicine medicine Humans Child education Survival rate Retrospective Studies Transplantation education.field_of_study business.industry Incidence (epidemiology) Hematopoietic Stem Cell Transplantation Retrospective cohort study Hematology respiratory system medicine.disease respiratory tract diseases Surgery Survival Rate Treatment Outcome Effusion Child Preschool Cohort business circulatory and respiratory physiology |
| Zdroj: | Bone Marrow Transplantation. 46:529-538 |
| ISSN: | 1476-5365 0268-3369 |
| Popis: | The objective of this study was to assess the incidence, risk factors, outcome and impact on OS of pericardial effusion (PEF) in a cohort of 156 pediatric SCT recipients. The mean age was 8.15±6.25 years. In all, 74% of the patients had malignant disease and 35% of the patients received autologous stem cell grafts. Twenty-three subjects developed effusion at 2.75±3.54 months after SCT. The overall probability of developing a PEF after SCT was 16.9%. In the multivariate analysis of risk factors associated with time to PEF, increased age, allogeneic risk status and conditioning type, were all significant factors. In a multivariate analysis of time to death, PEF, CMV status and risk status were all independent risk factors. PEF, however, had the highest HR of 3.334. Of the 23 patients with PEF, 19 died (82.6%); however, none died as a direct result of pericardial tamponade. In summary, our results suggest that PEF is a significant risk factor for post transplant mortality. These results suggest a need for more frequent evaluation and monitoring for development of PEF. Studies are needed to determine the etiology of, and new therapeutic strategies for, PEF in the post-SCT population. |
| Databáze: | OpenAIRE |
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