Antimicrobial Resistance Among Nontyphoidal Salmonella Isolated From Blood in the United States, 2003-2013
| Autor: | Cindy R. Friedman, Beth E. Karp, Kristina M. Angelo, Christina M. Scheel, Robert M. Hoekstra, Jared Reynolds |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Serotype Adult Male Salmonella Adolescent Tetracycline 030106 microbiology Bacteremia medicine.disease_cause Serogroup Article Microbiology 03 medical and health sciences Young Adult Antibiotic resistance Risk Factors Drug Resistance Bacterial medicine Immunology and Allergy Humans Child Feces Aged Aged 80 and over business.industry Infant Newborn Infant Middle Aged Antimicrobial medicine.disease Virology United States Anti-Bacterial Agents Infectious Diseases Child Preschool Salmonella Infections Ceftriaxone Female business medicine.drug |
| Zdroj: | The Journal of infectious diseases. 214(10) |
| ISSN: | 1537-6613 |
| Popis: | Background Salmonella causes an estimated 100 000 antimicrobial-resistant infections annually in the United States. Salmonella antimicrobial resistance may result in bacteremia and poor outcomes. We describe antimicrobial resistance among nontyphoidal Salmonella blood isolates, using data from the National Antimicrobial Resistance Monitoring System. Methods Human nontyphoidal Salmonella isolates from 2003 to 2013 were classified as fully susceptible, resistant to ≥1 antimicrobial agent, or resistant to a first-line agent. Logistic regression was used to compare resistance patterns, serotypes, and patient characteristics for Salmonella isolated from blood versus stool and to determine resistance trends over time. Results Approximately 20% of blood isolates had antimicrobial resistance to a first-line treatment agent. Bacteremia was associated with male sex, age ≥65 years, and specific serotypes. Blood isolates were more likely to be resistant to ≥1 agent for serotypes Enteritidis, Javiana, Panama, and Typhimurium. Blood isolates were most commonly resistant to tetracycline (19%), and more likely resistant to a first-line agent (odds ratio, 1.81; 95% confidence interval, 1.56-2.11) than stool isolates. Ceftriaxone resistance increased in blood isolates from 2003 to 2013 (odd ratio, 1.12; 95% confidence interval, 1.02-1.22). Conclusions Resistance to first-line treatment agents in patients with Salmonella bacteremia is a concern for public health and for informing clinical decisions. Judicious antimicrobial use is crucial to limit resistance. |
| Databáze: | OpenAIRE |
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