MAMI: a birth cohort focused on maternal-infant microbiota during early life

Autor: García Mantrana, Izaskun, Alcántara, Cristina, Selma Royo, Marta, Boix Amorós, Alba, Dzidic, Majda, Gimeno Alcañiz, Jose, Úbeda Sansano, Isabel, Sorribes Monrabal, Ignacio, Escuriet Peiró, Ramón, 1968, Gil Raga, Fernando, Parra Llorca, Anna, Martínez Costa, Cecilia, Collado, María Carmen, MAMI team
Přispěvatelé: European Research Council, Consejo Superior de Investigaciones Científicas (España)
Rok vydání: 2018
Předmět:
Male
Meconium
Fetus -- Creixement
Growth
Polymerase Chain Reaction
Cohort Studies
Study Protocol
0302 clinical medicine
Child Development
Antibiotics
Medicine
030212 general & internal medicine
Prospective Studies
health care economics and organizations
2. Zero hunger
Microbiota
Confounding
lcsh:RJ1-570
Age Factors
Gestational age
Early life
Mother-Child Relations
3. Good health
Breast Feeding
Female
Birth cohort
Cohort study
Microquímica
Adult
Breast milk
Births
Gestational Age
Early nutrition
03 medical and health sciences
Sex Factors
Embaràs -- Aspectes nutricionals
030225 pediatrics
Environmental health
Humans
Lactation
Infant Health
Monitoring
Physiologic
Pregnancy
business.industry
Infant
Newborn
Infant
Neonates
lcsh:Pediatrics
DNA
Anthropometry
medicine.disease
Diet
Gastrointestinal Microbiome
Spain
Pediatrics
Perinatology and Child Health
Multivariate Analysis
Birth
business
Zdroj: BMC Pediatrics
Digital.CSIC. Repositorio Institucional del CSIC
instname
BMC Pediatrics, Vol 19, Iss 1, Pp 1-8 (2019)
ISSN: 1471-2431
Popis: [Background] Early microbial colonization is a relevant aspect in human health. Altered microbial colonization patterns have been linked to an increased risk of non-communicable diseases (NCDs). Advances in understanding host-microbe interactions highlight the pivotal role of maternal microbiota on infant health programming. This birth cohort is aimed to characterize the maternal microbes transferred to neonates during the first 1000 days of life, as well as to identify the potential host and environmental factors, such as gestational age, mode of delivery, maternal/infant diet, and exposure to antibiotics, which affect early microbial colonization.
[Methods] MAMI is a prospective mother-infant birth cohort in the Spanish-Mediterranean area. Mothers were enrolled at the end of pregnancy and families were follow-up during the first years of life. Maternal-infant biological samples were collected at several time points from birth to 24 months of life. Clinical and anthropometric characteristics and dietary information is available. Specific qPCR and 16S rRNA gene sequencing as well as short chain fatty acid (SCFAs) profile would be obtained. Multivariable models will be used to identy associations between microbiota and clinical and anthropometric data controlling for confounders. MAMI would contribute to a better understanding of the interaction between diet, microbiota and host response in early life health programming, enabling new applications in the field of personalized nutrition and medicine.
MAMI team would like to acknowledge the support from H2020-ERC Starting Grant 639226.
We acknowledge support of the publication fee by the CSIC Open Access Support Initiative through its Unit of Information Resources for Research (URICI)
Databáze: OpenAIRE
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